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Comment & Response |

Self-Reported Sleep and β-Amyloid Deposition in Older Adults—Reply

Adam P. Spira, PhD1; Yang An, MS2; Susan M. Resnick, PhD2
[+] Author Affiliations
1Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
2Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
JAMA Neurol. 2014;71(5):651-652. doi:10.1001/jamaneurol.2014.167.
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In Reply Dr Kawada raised several concerns with our article.1 First, we acknowledge that there were relatively few participants reporting restless sleep or extremely short sleep duration in our sample. However, we treated sleep quality and duration as continuous variables in our regression models, and our sample provided adequate power across the range of values to detect significant associations between reports of worse sleep and greater β-amyloid deposition. Although further research is warranted, our results may indicate that sleep need not be extremely restless or of very short duration to show an association with β-amyloid burden.


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May 1, 2014
Tomoyuki Kawada, MD, PhD
1Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
JAMA Neurol. 2014;71(5):651. doi:10.1001/jamaneurol.2013.6417.
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