Accepted for Publication: March 12, 2014.
Published Online: April 28, 2014. doi:10.1001/jamaneurol.2014.585.
Study concept and design: Burkholder, Cascino, Worrell.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Burkholder, Worrell.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Burkholder.
Obtained funding: Worrell.
Study supervision: Worrell.
Conflict of Interest Disclosures: Dr Worrell consults for and has received research support from Medtronic Inc, Neuralynx Inc, and Neuropace Inc. No other disclosures were reported.
Funding/Support: This research was supported by a generous gift from Mr and Mrs David Hawk, grant UL1TR000135 from the Mayo Clinic Center for Translational Science Activities, grant IGA MZCR NT/11536-5 from the Ministry of Health of the Czech Republic, Project FNUSA-ICRC (grant CZ.1.05/1.1.00/02.0123) from the European Regional Development Fund, and grant CZ.1.07/2.3.00/20.0117 from the European Social Fund Young Talent Incubator II. Dr Worrell is supported by grant R01-NS63039 from the National Institutes of Health.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Karla Crockett and Cindy Nelson, Department of Neurology, Mayo Clinic, provided technical support. They did not receive compensation.