Accepted for Publication: February 19, 2014.
Published Online: April 21, 2014. doi:10.1001/jamaneurol.2014.445.
Study concept and design: Li, Millard, Peskind, Raskind, Galasko, Montine.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Li, Millard, Zhang, Montine.
Critical revision of the manuscript for important intellectual content: Li, Millard, Peskind, Yu, Leverenz, Mayer, Shofer, Raskind, Quinn, Galasko, Montine.
Statistical analysis: Millard, Shofer, Montine.
Obtained funding: Peskind, Leverenz, Raskind, Galasko, Montine.
Administrative, technical, or material support: Peskind, Zhang, Yu, Mayer, Raskind, Galasko, Montine.
Study supervision: Li, Peskind, Raskind, Montine.
Conflict of Interest Disclosures: Dr Leverenz serves as a consultant for Boehringer Ingelheim, Navidea Biopharmaceuticals, and Piramal Health Care. Dr Galasko serves as editor of Alzheimerʼs Disease Research and Treatment; serves on data safety monitoring boards for Elan, Janssen, and Balance Pharmaceuticals; and is a consultant for Elan Pharmaceuticals, Inc, and Genentech, Inc. He receives research support from the National Institutes of Health, the Michael J. Fox Foundation, and the Alzheimerʼs Drug Discovery Foundation. Dr Montine receives grants from the National Institutes of Health and personal compensation in the form of honoraria from invited scientific presentations to universities and professional societies not exceeding $5000 per year. No other disclosures were reported.
Funding/Support: This work was supported by National Institutes of Health grants AG023185, AG031892, AG05131, AG05136, AG08017, AG033693, and U01-NS082137; the Department of Veterans Affairs; the Oregon Clinical and Translational Research Institute grant UL1TR000128; the Jane and Lee Seidman Fund; and the Nancy and Buster Alvord Endowment.
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Kathleen Montine, PhD, Department of Pathology, School of Medicine, University of Washington, provided editorial assistance. No financial compensation was provided.