Accepted for Publication: February 5, 2014.
Published Online: April 21, 2014. doi:10.1001/jamaneurol.2014.313.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Alcalay, Dinur.
Critical revision of the manuscript for important intellectual content: Quinn, Sakanaka, Levy, Waters, Fahn, Dorovski, Chung, Pauciulo, Nichols, Rana, Balwani, Bier, Elstein, Zimran.
Statistical analysis: Alcalay.
Obtained funding: Alcalay.
Administrative, technical, or material support: Dinur, Pauciulo, Rana, Elstein.
Study supervision: Chung, Balwani, Zimran.
Conflict of Interest Disclosures: Dr Waters has received speaking honoraria from Teva and UCB. Dr Fahn receives consulting and advisory board membership with honoraria from Merz Pharma and Genervon Biotechnology and expects to receive compensation for serving as principal investigator of a pilot clinical trial. Dr Fahn has received lecture honoraria at the American Academy of Neurology, Columbia University, and Sun Pharmaceuticals India, and is editor at and receives author honoraria from Springer Publishers for serving as coeditor of Current Neurology and Neurosurgery Report and Elsevier Publishers for coauthorship of the book titled Principles and Practice of Movement Disorders. Dr Balwani is a member of the International Collaborative Gaucher Group Registry advisory board and has received honoraria from Genzyme Corp. Dr Elstein has received honoraria and travel expenses to present data from clinical trials by Shire. Dr Zimran receives consultancy fees from and has options in Protalix Biotherapeutics and is a member of the scientific advisory board; he receives support from Genzyme Corp for participation in the International Collaborative Gaucher Group Registry and from SHGT for GOS, as well as honoraria from Pfizer and SHGT and travel compensation from Medison. No other disclosures were reported.
Funding/Support: Dr Alcalay receives research support from the National Institutes of Health (grant K02NS080915), the Parkinson’s Disease Foundation, the Smart Foundation, and the Michael J. Fox Foundation. Dr Levy is supported by the National Institutes of Health (grant K08-NS070608), as well as the Parkinson’s Disease Foundation and the Smart Foundation. Dr Waters receives research support from the Parkinson’s Disease Foundation. Dr Fahn receives grants/research support from the Parkinson’s Disease Foundation (no salary support) and the Smart Family Foundation. Dr Nichols receives support from the National Heart, Lung and Blood Institute (grants 5R01HL102107-04 and 5R24HL105333-02). Dr Balwani receives support from the National Institutes of Health (grant K23DK095946). The Department of Genetics and Genomic Sciences at Mount Sinai School of Medicine receives support for participation in the International Collaborative Gaucher Group Registry. Funding for this study was provided by the Parkinson’s Disease Foundation, the National Institutes of Health (grants K02 NS080915, R56NS036630, and UL1 TR000040, formerly the National Center for Research Resources, grant UL1 RR024156, and grant UL1RR 029887 from the National Center for Research Resources), and the Department of Genetics and Genomic Sciences at Mount Sinai School of Medicine.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.