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Comment & Response |

Neuronal Antibodies in Creutzfeldt-Jakob Disease

Koji Fujita, MD, PhD1; Keiko Tanaka, MD, PhD2; Yukitoshi Takahashi, MD, PhD3
[+] Author Affiliations
1Department of Clinical Neuroscience, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
2Department of Neurology, Kanazawa Medical University, Ishikawa, Japan
3National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
JAMA Neurol. 2014;71(4):514. doi:10.1001/jamaneurol.2014.27.
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To the Editor Grau-Rivera et al1 reported that in their study, none of the 49 patients with definite Creutzfeldt-Jakob disease (CJD) revealed antibodies against neuronal surface antigens, including N-methyl-D-aspartate receptors (NMDARs), in the cerebrospinal fluid (CSF). In this article, they referred to previous studies2,3 and criticized that anti-NMDAR antibodies in patients with CJD had been reported in the serum alone and that analysis of CSF antibodies should be included to avoid potential pitfalls. However, we demonstrated that one of the patients with sporadic CJD, positive for abnormal prion protein (PrPSc) in CSF according to real-time quaking-induced conversion, had CSF antibodies against NMDAR examined with a cell-based assay using human embryonic kidney 293 cells cotransfected with NR1 and NR2 cDNA.4 Therefore, CSF antibodies against NMDAR do not always rule out the diagnosis of CJD.


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April 1, 2014
Francesc Graus, MD, PhD; Josep Dalmau, MD, PhD
1Department of Neurology, Hospital Clínic, Barcelona, Spain2Institut d’Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain
2Institut d’Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain3Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain4Department of Neurology, University of Pennsylvania, Philadelphia
JAMA Neurol. 2014;71(4):514-515. doi:10.1001/jamaneurol.2014.30.
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