0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Neuronal Antibodies in Creutzfeldt-Jakob Disease

Koji Fujita, MD, PhD1; Keiko Tanaka, MD, PhD2; Yukitoshi Takahashi, MD, PhD3
[+] Author Affiliations
1Department of Clinical Neuroscience, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
2Department of Neurology, Kanazawa Medical University, Ishikawa, Japan
3National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
JAMA Neurol. 2014;71(4):514. doi:10.1001/jamaneurol.2014.27.
Text Size: A A A
Published online

Extract

To the Editor Grau-Rivera et al1 reported that in their study, none of the 49 patients with definite Creutzfeldt-Jakob disease (CJD) revealed antibodies against neuronal surface antigens, including N-methyl-D-aspartate receptors (NMDARs), in the cerebrospinal fluid (CSF). In this article, they referred to previous studies2,3 and criticized that anti-NMDAR antibodies in patients with CJD had been reported in the serum alone and that analysis of CSF antibodies should be included to avoid potential pitfalls. However, we demonstrated that one of the patients with sporadic CJD, positive for abnormal prion protein (PrPSc) in CSF according to real-time quaking-induced conversion, had CSF antibodies against NMDAR examined with a cell-based assay using human embryonic kidney 293 cells cotransfected with NR1 and NR2 cDNA.4 Therefore, CSF antibodies against NMDAR do not always rule out the diagnosis of CJD.

Topics

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

April 1, 2014
Francesc Graus, MD, PhD; Josep Dalmau, MD, PhD
1Department of Neurology, Hospital Clínic, Barcelona, Spain2Institut d’Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain
2Institut d’Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain3Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain4Department of Neurology, University of Pennsylvania, Philadelphia
JAMA Neurol. 2014;71(4):514-515. doi:10.1001/jamaneurol.2014.30.
CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

295 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Jobs
brightcove.createExperiences();