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In This Issue of JAMA Neurology |

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JAMA Neurol. 2014;71(4):383-385. doi:10.1001/jamaneurol.2013.4141.
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Bos and coauthors investigate the relationship between intracranial carotid artery calcification as a marker of intracranial atherosclerosis and the risk of stroke in a white population.

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Hughes and colleagues quantitatively evaluate the performance of Alzheimer disease centers by analyzing copublication networks among the centers.

Jackson et al determine the diagnostic accuracy of a prototype blood test for variant Creutzfeldt-Jakob disease and its suitability for clinical use and screening prion-exposed populations.

Shulman and colleagues evaluate 18 candidate single-nucleotide polymorphisms to determine whether Parkinson disease susceptibility loci are associated with parkinsonism or substantia nigra pathology.

Cohen and coauthors collect data from patients with multiple sclerosis (MS) switching from natalizumab to fingolimod. They performed a survey-based, observational multicenter cohort study among MS tertiary referral centers. Main outcomes and measures were the occurrence of MS relapse during the washout period or during a 6-month follow-up period after the initiation of fingolimod.

Grossman et al conduct a case-control study using phosphorylated tau to identify a biomarker for amyotrophic lateral sclerosis (ALS).

Cady and coauthors investigate whether p.R47H (rs75932628) in TREM2 is a risk factor for amyotrophic lateral sclerosis and assess whether TREM2 expression is dysregulated in disease.

Yoo and colleagues evaluate the incidence of brief ictal rhythmic discharges in critically ill patients and investigate their association with seizures and outcomes.

Videnovic et al examine the endogenous circadian rhythm of melatonin secretion in patients with Parkinson disease and healthy control individuals using a modified constant routine protocol to assess human endogenous rhythmicity.

Cadieux-Dion and coauthors map and identify the causative gene in a large French-Canadian family with autosomal dominant spinocerebellar ataxia and erythrokeratodermia variabilis.

Skillbäck and colleagues test the diagnostic performance of dementia cerebrospinal fluid biomarkers total tau (T-tau), phosphorylated tau (P-tau), and the T-tau to P-tau ratio for Creutzfeldt-Jakob disease.


Uflacker et al describe the use of preimplantation genetic diagnosis and in vitro fertilization for the prevention of genetic prion disease in the children of a 27-year-old asymptomatic woman with a family history of Gerstmann-Sträussler-Scheinker syndrome.

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