Accepted for Publication: February 7, 2014.
Published Online: March 31, 2014. doi:10.1001/jamaneurol.2014.186.
Study concept and design: Hughes, DeKosky, Lopez.
Acquisition, analysis, or interpretation of data: Kuller, Barinas-Mitchell, McDade, Klunk, Cohen, Mathis, Price, Lopez.
Drafting of the manuscript: Hughes, Lopez.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Hughes.
Obtained funding: DeKosky, Lopez.
Administrative, technical, or material support: DeKosky, Price, Lopez.
Study supervision: Hughes, Kuller, DeKosky, Lopez.
Conflict of Interest Disclosures: Dr Klunk reported being a coinventor of Pittsburgh compound B, a technology described in this study. As such, he has a financial interest in the license agreement, which GE Healthcare holds with the University of Pittsburgh. He reported serving as a consultant to GE Healthcare, Janssen, Pfizer, Lilly, AstraZeneca, Wyeth, Roche, and Elan. Dr Mathis reported being a coinventor of Pittsburgh compound B, a technology described in this study. As such, he has a financial interest in the license agreement, which GE Healthcare holds with the University of Pittsburgh. He reported serving as a consultant for GE Healthcare, Elan/Wyeth, Novartis, Janssen, Genzyme, Pfizer, Bristol Myers Squibb, IBA, and Baxter Bioscience. Dr Lopez reported serving as a consultant for Lilly, Lundbeck, Merz, and Baxter. No other disclosures are reported.
Funding/Support: This study was supported by grants P50 AG005133, R37 AG025516, and P01 AG025204 and NIA T32 postdoctoral training grant T32 AG000181 (Dr Hughes) from the National Institutes of Health.
Role of the Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.