Accepted for Publication: February 3, 2014.
Published Online: March 31, 2014. doi:10.1001/jamaneurol.2014.65.
Study concept and design: Breen, Vuono, Shneerson, Reddy, Barker.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Breen, Barker.
Critical revision of the manuscript for important intellectual content: Vuono, Nawarathna, Fisher, Schneerson, Reddy.
Statistical analysis: Breen, Barker.
Administrative, technical, or material support: Breen, Vuono, Nawarathna, Shneerson, Barker.
Study supervision: Shneerson, Reddy, Barker.
Conflict of Interest Disclosures: None reported.
Funding/Support: We acknowledge the study funders: the Big Lottery Fund via Parkinson’s UK (grant C498A738) and a National Institute of Health Research Biomedical Research Award to Addenbrooke’s Hospital/University of Cambridge. Dr Breen has been a recipient of a Raymond and Beverly Sackler Studentship. Dr Reddy acknowledges funding from the Wellcome Trust (grant 100333/Z/12/Z). We acknowledge Roche Applied Science for the generous loan of the Light Cycler 480 instrument on which we performed the clock gene analysis.
Role of the Sponsor: Parkinson’s UK reviewed the initial grant application but had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank staff at the Wellcome Trust Clinical Research Facility in Addenbrooke’s Hospital, Cambridge, for performing the circadian blood sampling as well as staff at the Respiratory and Sleep Support Centre in Papworth Hospital, Cambridge, for their support and assistance throughout the study. We are grateful to Alpar Lazar, PhD, John van Geest Centre for Brain Repair, University of Cambridge, for helpful suggestions during preparation of the manuscript and Jonathan Evans, PhD, John van Geest Centre for Brain Repair, University of Cambridge, for helping recruit patients to the PICNICS study and carrying out clinical assessments. We acknowledge Neil Goddard, PhD, Roche Applied Science, for technical advice during the experiments.