Accepted for Publication: January 17, 2014.
Published Online: March 17, 2014. doi:10.1001/jamaneurol.2014.99.
Study concept and design: Popa, Milani, Rothwell, Vidailhet, Meunier, Roze.
Acquisition, analysis, or interpretation of data: Popa, Milani, Richard, Hubsch, Brochard, Tranchant, Sadnicka, Meunier, Roze.
Drafting of the manuscript: Meunier.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Popa, Milani, Richard, Hubsch, Meunier.
Obtained funding: Rothwell, Vidailhet, Meunier, Roze.
Administrative, technical, or material support: Brochard, Tranchant, Sadnicka.
Study supervision: Popa, Milani, Richard, Hubsch, Brochard, Meunier, Roze.
Conflict of Interest Disclosures: Dr Popa received support from Institut National de la Santé et de la Recherche Médicale (INSERM), Institute of Translational Neuroscience, Paris, France. Dr Rothwell received honoraria from the Movement Disorders Society and the International Federation of Clinical Neurophysiology and research grants from the European Union and Medical Research Council of the United Kingdom. Dr Vidailhet received research grants from Metz, UCB, Novartis, INSERM (le Comité d’Orientation Stratégique et de Suivi des Essais Cliniques [COSSEC]), Agence Nationale de la Recherche, patients’ associations (France Parkinson and Association des Malades Atteints de Dystonie), and travel grants from Movement Disorders Society and Dystonia Coalition. Dr Roze received research support from INSERM (COSSEC), AP-HP (Direction de la Recherche Clinique, Programme Hospitalier de Recherche Clinique), Fondation pour la Recherche sur le Cerveau, the Dystonia Coalition (pilot project), Ipsen, Merz-Pharma, Novartis, Teva, Lundbeck, and Orkyn; served on scientific advisory boards for Orkyn, Ipsen, and Merz-pharma; received speech honorarium from Novartis and Orkyn; and received travel funding from Teva, Novartis, the Dystonia Coalition, the Movement Disorders Society, the World Federation of Neurology Association of Parkinsonism and Related Disorders, and the International Federation of Clinical Neurophysiology. No other disclosures were reported.
Funding/Support: This study was supported by the Dystonia Medical Research Foundation and the Brown family; by grant ANR-10-IAIHU-06 from the program Investissements d’avenir (Dr Popa); by a grant from Fondation Groupama (Dr Hubsch); and by grant “poste d’accueil” from the AP-HP/Centre National de la Recherche Scientifique (Dr Roze).
Role of the Sponsors: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; the preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: The Centre for Clinical Investigations No. 9503 of the Hôpital Pitié Salpêtrière provided logistic support for the clinical investigation of the patients. The platform “Gait, Equilibrium, Posture, Movement, TMS, and Navigated Brain Stimulation” of Centre de Recherche de l’Institut du Cerveau et de la Moëlle provided material support for performing all electrophysiological measurements.