Accepted for Publication: January 17, 2014.
Published Online: March 17, 2014. doi:10.1001/jamaneurol.2014.94.
Study concept and design: Singh, Mielke, Roberts, Geda, Petersen.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Singh, Mielke, Parsaik, Roberts, Petersen.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Singh, Mielke, Cha, Christianson, Pankratz.
Obtained funding: Petersen.
Administrative, technical, or material support: Petersen.
Study supervision: Mielke, Roberts, Scanlon, Petersen
Conflict of Interest Disclosures: Dr Mielke receives research support from the National Institute on Aging, National Institutes of Health (NIA/NIH) and has served as a consultant for Eli Lilly. Dr Roberts receives research support from the NIA/NIH and from Abbvie Health Economics and Outcomes Research. Dr Scanlon has participated as an investigator in clinical trials funded by Boehringer Ingelheim, GlaxoSmithKline, Forest, Novartis, and Pearl Therapeutics and has served as a consultant to GlaxoSmithKline and Merck. Dr Petersen serves on scientific advisory boards for Pfizer, Inc, Janssen Alzheimer Immunotherapy, Elan Pharmaceuticals, and GE Healthcare, receives royalties from the publication of Mild Cognitive Impairment (Petersen RC, ed. New York, NY: Oxford University Press; 2003), and receives research support from the NIA/NIH. No other disclosures were reported.
Funding/Support: This study was supported by grants P50 AG016574, U01 AG006786 (under which study participants were enrolled), K01 MH068351, and K01 AG028573 from the NIH; by the Robert H. and Clarice Smith and Abigail van Buren Alzheimer’s Disease Research Program; by Clinical and Translational Science Award UL1 TR000135 from the National Center for Advancing Translational Sciences, a component of the NIH; and by grant R01 AG034676 from the REP.
Role of the Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.