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Editorial |

A Brighter Future for Patients With Amyotrophic Lateral Sclerosis Through Imaging?

Bradley R. Foerster, MD, PhD1,2,3; Eva L. Feldman, MD, PhD4
[+] Author Affiliations
1Department of Radiology, University of Michigan, Ann Arbor
2VA Ann Arbor Healthcare System, Ann Arbor, Michigan
3Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
4Department of Neurology, University of Michigan, Ann Arbor
JAMA Neurol. 2014;71(5):539-540. doi:10.1001/jamaneurol.2014.66.
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Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous disease and presents with varying degrees of upper motor and lower motor neuron involvement. In certain cases, diagnosis can be challenging even for an experienced neurologist. Electrophysiology supplements the physical examination for detection of lower motor neuron involvement and is combined with the neurological examination to diagnose ALS and define the degree of diagnostic certainty: possible, probable, or definite ALS. Traditionally, neuroimaging has played a role in excluding other diseases that can present with both upper motor and lower motor neuron signs (eg, a high cervical spinal cord lesion or a syrinx).

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