Accepted for Publication: December 17, 2013.
Published Online: February 24, 2014. doi:10.1001/jamaneurol.2013.6239.
Study concept and design: Videnovic, Zee.
Acquisition of data: Videnovic, Marconi.
Analysis and interpretation of data: All authors.
Drafting of the manuscript: Videnovic.
Critical revision of the manuscript for important intellectual content: Noble, Reid, Peng, Turek, Marconi, Rademaker, Simuni, Zadikoff, Zee.
Statistical analysis: Rademaker.
Study supervision: Videnovic, Zee.
Conflict of Interest Disclosures: Dr Videnovic has received research grant support from the American Academy of Neurology Foundation, Parkinson’s Disease Foundation, National Institutes of Health (K23 NS072283), and Michael J. Fox Foundation for Parkinson’s Research. Dr Reid has received grant support from the American Waterway Operators and Philips Consumer Lifestyles and is a consultant for the American Waterways Operators. Dr Turek is a consultant for Merck Inc, Servier, Vanda Pharmaceuticals, Philips Respironics, and Ingram Barge Company and has received research support from the National Institutes of Health (NIH) (P01 AG011412 and R01AA020216), Merck Inc, Servier, American Waterways Operators, March of Dimes, and Department of Defense. Dr Rademaker has received honoraria from serving as an external advisory board member for Georgetown University and research support from the NIH. Dr Simuni is a consultant for Novartis, Ibsen, General Electric, UCB Pharma, Teva, and Boehringer Ingelheim and received grant support from the NIH (grants U01 NS050324-01A1, U01 NS050095-03, and U10 NS053377-02), Michael J. Fox Foundation for Parkinson’s Research, Teva, and Takeda. Dr Zadikoff is a consultant for Teva, Ipsen, Merz, and Abbott Laboratories and has received honoraria for speaking engagements from Teva, UCB Pharma, and GSK. Dr Zee is a consultant for sanofi-aventis, UCB, Johnson & Johnson, Merck, Takeda, Phillips, Purdue, Jazz, Vanda, and Ferring; has stock ownership with Teva; and has received research support from the NIH (grants R01 HL090873, R01 HL105549, P01 AG11412, and UM1HL112856). No other disclosures were reported.
Funding/Support: This study was supported by grant K23 NS072283 from the National Institute of Neurological and Communicative Disorders and Stroke, NIH (Dr Videnovic); by a Clinical Scientist Development Award from the American Brain Foundation/Parkinson’s Disease Foundation; by grant 5P01 AG011412-17 from the National Institute on Aging, NIH (Dr Turek); and by grant 8UL1TR000150 from the National Center for Advancing Translational Sciences.
Role of the Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Elizabeth B. Klerman, MD, PhD (Division of Sleep Medicine, Harvard Medical School), reviewed the manuscript.