Accepted for Publication: December 12, 2013.
Published Online: February 10, 2014. doi:10.1001/jamaneurol.2013.6225.
Study concept and design: Hughes, Hogenesch, Trojanowski.
Acquisition of data: Hughes, Peeler, Trojanowski.
Analysis and interpretation of data: Hughes, Hogenesch, Trojanowski.
Drafting of the manuscript: Hughes, Trojanowski.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Hughes, Trojanowski.
Obtained funding: Hogenesch, Trojanowski.
Administrative, technical, or material support: All authors.
Study supervision: Hogenesch, Trojanowski.
Conflict of Interest Disclosures: Dr Trojanowski is the principal investigator of the Penn ADC.
Funding/Support: This work was supported by an award from the National Institute on Aging through the National Alzheimer’s Coordinating Center (UO1 AG016976) to the Penn ADC (AG10124) and by grant 5-UL1-TR000003-08 (National Center for Advancing Translational Sciences) to Garret FitzGerald. Dr Hogenesch is supported by National Institutes of Health grants 2-R01-NS054794-06 and 5-R01-HL097800-04 and by Defense Advanced Research Projects Agency 12-DARPA-1068 (John Harer, Duke University).
Role of the Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank members of the laboratories of Drs Hogenesch and Trojanowski for helpful suggestions during the preparation of the manuscript. Assistance with accessing and analyzing the evolving ADC rosters was provided by Maggie Dean, BS, and Walter Kukull, PhD (University of Washington); Creighton Phelps, PhD, and Robin Barr, DPhil (NIH/NIA); Mary Sundsmo, MBA (University of California, San Diego); Leslie Dunn, MPH (University of Pittsburgh Medical Center); Penny Sansing-Edwards, MA (Duke University Medical Center); Laura Hughes, PhD (Stanford University); and Amy Ashbridge, MBA, Julie Baggs, PhD, Ed Pieters PhD, Matthew Merz, BS, Elisabeth McCarty, MS, CGC, and Kyle Stephens, MA (University of Pennsylvania School of Medicine).