Accepted for Publication: November 13, 2013.
Published Online: February 3, 2014. doi:10.1001/jamaneurol.2013.5884.
Study concept and design: Uflacker, Doraiswamy, Rechitsky, Geschwind, Tur-Kaspa.
Acquisition of data: Rechitsky, See, Geschwind, Tur-Kaspa.
Analysis and interpretation of data: Uflacker, Doraiswamy, Rechitsky, Geschwind, Tur-Kaspa.
Drafting of the manuscript: Uflacker, Doraiswamy, Tur-Kaspa.
Critical revision of the manuscript for important intellectual content: Uflacker, Doraiswamy, Rechitsky, See, Geschwind, Tur-Kaspa.
Obtained funding: Doraiswamy, Rechitsky, Geschwind, Tur-Kaspa.
Administrative, technical, and material support: Doraiswamy, Geschwind.
Study supervision: Doraiswamy, Rechitsky, Geschwind, Tur-Kaspa.
Conflict of Interest Disclosures: Dr Doraiswamy has received research grants (through Duke University) from Elan, Avid, Lilly, Novartis, Neuronetrix, Medivation, Wyeth, Janssen, Pfizer, and National Institutes of Health (NIH) over the past 3 years. He has received advisory or speaking fees in the past from Accera, Avid, AstraZeneca, Abbvie, Baxter, Cognoptix, Lundbeck, Takeda, Piramal, Genomind, Sonexa, Shire, Targacept, Grifols, Neuronetrix, TauRx, Medivation, Danone, Neurocog Trials, Alzheimer’s Association, Alzheimer’s Foundation, University of California, National University of Singapore, and University of Copenhagen. He owns shares in Maxwell Health, Sonexa, Clarimedix, and Adverse Events Inc, whose products are not discussed here. Dr Rechitsky is employed by the Reproductive Genetic Institute, where the PGD procedure was performed. Dr Tur-Kaspa is employed by the Institute for Human Reproduction, where the IVF was performed. No other disclosures were reported.
Funding/Support: Drs Uflacker and Doraiswamy did not receive any specific external support for this work. Drs Rechitsky and Tur-Kaspa were supported by the Reproductive Genetics Institute and the Institute for Human Reproduction, Chicago, Illinois, respectively. Dr Geschwind was supported in part by National Institute on Aging/National Institutes of Health (NIH) grants R01 AG031189 and P50 AG023501; NIH/National Center for Research Resources, University of California San Francisco Clinical and Translational Science Institute grant UL1 RR024131; The Michael J. Homer Family Fund; and Alzheimer’s Disease Research Center of California grant 10-10030.
Role of the Sponsor: The supporting institutions had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We are grateful to our patient for allowing her case to be presented in this publication.