Accepted for Publication: October 30, 2013.
Published Online: January 20, 2014. doi:10.1001/jamaneurol.2013.5699.
Study concept and design: Wingerchuk, Palace, Greenberg, Levy.
Acquisition of data: Mealy, Wingerchuk, Greenberg, Levy.
Analysis and interpretation of data: Mealy, Wingerchuk, Levy.
Drafting of the manuscript: Mealy, Levy.
Critical revision of the manuscript for important intellectual content: All authors.
Administrative, technical, or material support: Mealy, Greenberg, Levy.
Study supervision: Palace, Levy.
Conflict of Interest Disclosures: Dr Wingerchuk receives research support from Alexion, Genentech, Genzyme Corporation, Terumo BCT, and the Guthy-Jackson Charitable Foundation and serves as a consultant for Alexion and MedImmune. Dr Palace has received support for scientific meetings and honorariums for advisory committees or consultancy work from Merck Serono, Biogen Idec, Novartis, Teva, Chugai Pharma, and Bayer Schering; unrestricted grants from Merck Serono and Bayer Schering; and grants from the Multiple Sclerosis Society for unrelated research studies. Her hospital trust receives funds for her role as clinical lead for the UK Multiple Sclerosis Risk Sharing Scheme Study. Dr Greenberg has received consulting income from DioGenix, Amplimmune, GlaxoSmithKline, Chugai Pharmaceuticals, and Biogen Idec; has received grants from the National Institutes of Health, Guthy-Jackson Charitable Foundation, Accelerated Cure Project, and Patient Centered Outcomes Research Institutes; and has equity in Amplimmune and DioGenix. Dr Levy receives research support from the National Institutes of Health, Guthy-Jackson Charitable Foundation, Acorda, Sanofi, NeuralStem, and Genentech and serves as a consultant for Chugai Pharmaceuticals, GlaxoSmithKline, and Medimmune. No other disclosures were reported.
Funding/Support: This study was supported by the Guthy-Jackson Charitable Foundation.
Role of the Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; the preparation, review, or approval of the manuscript; and the decision to submit the manuscript for publication.
Additional Contributions: Changwan Lu, PhD, at EZBiostat.com provided assistance with statistical analysis.