Accepted for Publication: October 22, 2013.
Published Online: January 13, 2014. doi:10.1001/jamaneurol.2013.5570.
Study concept and design: Vardarajan, Bennett, Sweet, Medrano, Mayeux.
Acquisition of data: Vardarajan, Faber, Bird, Bennett, Rosenberg, Boeve, Graff-Radford, Goate, Farlow, Sweet, Lantigua, Medrano, Foroud, Mayeux.
Analysis and interpretation of data: Vardarajan, Rosenberg, Boeve, Graff-Radford, Sweet, Ottman, Schaid, Foroud, Mayeux.
Drafting of the manuscript: Vardarajan, Mayeux.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Vardarajan, Schaid, Foroud, Mayeux.
Obtained funding: Bennett, Sweet, Ottman, Foroud, Mayeux.
Administrative, technical, or material support: Faber, Bennett, Graff-Radford, Goate, Farlow, Lantigua, Medrano, Mayeux.
Study supervision: Bennett, Medrano, Mayeux.
Conflict of Interest Disclosures: Dr Boeve was an investigator for clinical trials sponsored by Cephalon, Inc, Allon Pharmaceuticals, and GE Healthcare; receives royalties from the publication of a book titled Behavioral Neurology of Dementia (Cambridge Medicine; 2009); has received honoraria from the American Academy of Neurology; serves on the Scientific Advisory Board of the Tau Consortium; and receives research support from the National Institute on Aging (NIA) (P50 AG016574, U01 AG006786, RO1 AG032306, RO1 AG041797) and the Mangurian Foundation. Dr Rosenberg has received clinical trial grants from Janssen and Pfizer Inc; holds a US patent for “Amyloid β Gene Vaccines”; and serves on the editorial board of the Journal of the Neurological Sciences. Dr Farlow has received grant and research support from Accera, Biogen, Eisai Med Res, Eli Lilly & Company, Genentech, MedAvante/AstraZeneca, and Navidea; serves on the speaker’s bureau at Eisai Med Res, Pfizer Inc, Forest, Novartis, and Eli Lilly & Company; serves on the consultant/advisory boards at Accera, Alltech, Avanir, Eisai Med Res, Inc, Helicon, Medavante, Medivation, Inc, Merck and Co, Inc, Novartis, Pfizer Inc, Prana Biotech, QR Pharma, Roche, Sanofi-Aventis, Schering-Plough, Toyama Pharm, Eli Lilly & Company, UCB Pharma and Elan. Dr Sweet is a consultant for Eli Lilly & Company. No other disclosures were reported.
Funding/Support: Study participants were enrolled under federal grants R01AG041797, U24AG026395, R37AG015473, and U24AG21886 from the NIA.
Role of the Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Group Information: The NIA-LOAD/NCRAD Family Study Group includes Badri N. Vardarajan, PhD; Kelley M. Faber, MS; Thomas D. Bird, MD; David A. Bennett, MD; Roger Rosenberg, MD; Bradley F. Boeve, MD; Neill R. Graff-Radford, MD; Alison M. Goate, DPhil; Martin Farlow, MD; Robert A. Sweet, MD; Rafael Lantigua, MD; Martin Z. Medrano, MD; Ruth Ottman, PhD; Daniel J. Schaid, PhD; Tatiana M. Foroud, PhD; and Richard Mayeux, MD, MSc.
Disclaimer: Dr Rosenberg is the Editor of JAMA Neurology and serves on the editorial board of JAMA. He was not involved in the editorial evaluation or decision to accept this article for publication.