Accepted for Publication: October 16, 2013.
Published Online: December 30, 2013. doi:10.1001/jamaneurol.2013.5489.
Study concept and design: Riku, Watanabe, Yoshida, Sobue.
Acquisition of data: Riku, Watanabe, Yoshida, Masuda, Senda, Sobue.
Analysis and interpretation of data: Riku, Watanabe, Yoshida, Tatsumi, Mimuro, Iwasaki, Katsuno, Iguchi, Ishigaki, Udagawa, Sobue.
Drafting of the manuscript: Riku, Watanabe, Yoshida, Sobue.
Critical revision of the manuscript for important intellectual content: Tatsumi, Mimuro, Iwasaki, Katsuno, Iguchi, Masuda, Senda, Ishigaki, Udagawa, Sobue.
Statistical analysis: Riku, Watanabe, Masuda, Senda.
Administrative, technical, or material support: Riku, Yoshida, Tatsumi, Mimuro, Iwasaki, Iguchi, Udagawa.
Study supervision: Watanabe, Yoshida, Katsuno, Senda, Sobue.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported by grants-in-aid from the Research Committee of Central Nervous System Degenerative Diseases by Ministry of Health, Labour, and Welfare and from Integrated Research on Neuropsychiatric Disorders, carried out under the Strategic Research for Brain Sciences by Ministry of Education, Culture, Sports, Science, and Technology of Japan.
Role of the Sponsor: The funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank all the patients, their families, and the staff in the affiliated hospitals for providing autopsy materials and clinical data.