Accepted for Publication: October 9, 2013.
Published Online: December 30, 2013. doi:10.1001/jamaneurol.2013.5402.
Study concept and design: Parsaik, Singh, Pankratz.
Acquisition of data: Parsaik, Singh, Roberts, Edwards, Geda, Knopman.
Analysis and interpretation of data: Parsaik, Roberts, Pankratz, Edwards, Gharib, Boeve, Knopman, Petersen.
Drafting of the manuscript: Parsaik, Singh, Gharib.
Critical revision of the manuscript for important intellectual content: Parsaik, Singh, Roberts, Pankratz, Edwards, Geda, Boeve, Knopman, Petersen.
Statistical analysis: Singh, Roberts, Pankratz, Edwards.
Obtained funding: Roberts, Petersen.
Administrative, technical, or material support: Parsaik, Roberts, Boeve.
Study supervision: Roberts, Pankratz, Knopman.
Conflict of Interest Disclosures: Dr Boeve has served as an investigator for clinical trials sponsored by Cephalon, Inc, Allon Pharmaceuticals, and GE Healthcare. He receives royalties from the publication of a book entitled Behavioral Neurology of Dementia (Cambridge Medicine; 2009). He has received honoraria from the American Academy of Neurology, serves on the Scientific Advisory Board of the Tau Consortium, and receives research support from the National Institute on Aging (grants P50 AG016574, U01 AG006786, RO1 AG032306, and RO1 AG041797) and the Mangurian Foundation. No other disclosures were reported.
Funding/Support: The study was funded by National Institutes of Health–National Institute on Aging grants K01 AG028573 (principal investigator [PI]: Dr Roberts), P50 AG016574 (PI: Dr Petersen), and U01 AG006786 (PI: Dr Petersen); by the National Institutes of Health–National Institute of Mental Health grant K01 MH068351 (PI: Dr Geda); and by the Robert H. and Clarice Smith and Abigail van Buren Alzheimer’s Disease Research Program.
Role of the Sponsors: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank the study participants and the Mayo Clinic Study of Aging team (coordinators, psychometrists, psychologists, program management team, and physicians) for their help in conducting this study.
Correction: This article was corrected on July 3, 2014, to fix the study design description in the Abstract.