Accepted for Publication: October 9, 2013.
Published Online: December 30, 2013. doi:10.1001/jamaneurol.2013.5390.
Study concept and design: Reed, Mack, DeCarli, Chui, Jagust.
Acquisition of data: Reed, Mack, DeCarli, Chui, Jagust.
Analysis and interpretation of data: Reed, Villeneuve, DeCarli, Chui, Jagust.
Drafting of the manuscript: Reed.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Reed, Villeneuve.
Obtained funding: Reed, DeCarli, Chui, Jagust.
Administrative, technical, or material support: Reed, Mack, DeCarli, Chui, Jagust.
Study supervision: DeCarli, Jagust.
Conflict of Interest Disclosures: Drs Reed, Mack, DeCarli, Chui and Jagust, have received support from the National Institutes of Health. Dr Villeneuve receives support from the Canadian Institutes of Health. Dr DeCarli serves as editor of Alzheimer’s Disease and Associated Disorders. Dr Jagust has served as a consultant to Genentech, Synarc, F. Hoffman-La Roche, and Janssen Alzheimer Immunotherapy.
Funding/Support: This study was supported by grants P01 AG12435 (Dr Chui), AG034570 (Dr Jagust), and P30 AG10129 (Dr DeCarli) from the National Institute on Aging.
Role of the Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Recruiters for the Aging Brain project, especially Nancy Gubbins, BA, and Gwendolyn Gates, BA, helped enroll the study participants. Lawrence Berkeley National Laboratory (Berkley, California) synthesized the tracer.