We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Images in Neurology |

Weil Syndrome A Rare Cause of Cerebral Venous Thrombosis

Thiago Cardoso Vale, MD1; Gustavo Camargos de Toledo Santos, MD1; Saulo Fernandes Saturnino, PhD, MD2; Adao Soares Antunes Neto3; Frederico Figueiredo Amâncio, MD2; Marluce Aparecida Assuncao Oliveira, PhD4; Breno Franco Silveira Fernandes, MD1; Rodrigo Santiago Gomez, MD1; Marcus Vinícius Andrade, MD, PhD2; Antonio Lucio Teixeira, MD, PhD2
[+] Author Affiliations
1Neurology Division, University Hospital, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
2Department of Internal Medicine, University Hospital, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
3medical student, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
4Tropical Medicine Division, Department of Internal Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
JAMA Neurol. 2014;71(2):238-239. doi:10.1001/jamaneurol.2013.2175.
Text Size: A A A
Published online


A 50-year-old previously healthy woman presented with a 4-day history of low back pain, nausea, vomiting, diarrhea, jaundice, and fever. She developed hypoxemic respiratory insufficiency and a chest radiograph showed diffuse alveolar and interstitial infiltrates. She was promptly intubated and became hemodynamically unstable and developed dialytic-renal insufficiency. At this time, laboratory workup revealed a hemoglobin level of 6.1 mg/dL (to convert to grams per liter, multiply by 10), leukocyte count of 0.2603/μL (to convert to ×109/L, multiply by 0.001), C-reactive protein level of 59 000 mg/L (to convert to nanomoles per liter, multiply by 9.524), platelet count of 28×103/μL (to convert to ×109/L, multiply by 1), serum urea level of 80 mg/dL (to convert to millimoles per liter, multiply by 0.357), serum creatinine level of 2.24 mg/dL (to convert to micromoles per liter, multiply by 88.4), serum potassium level of 0.72 mEq/L (to convert to millimoles per liter, multiply by 1), and abnormal coagulation profile (international normalized ratio of 1.8; D-dimer level of 125 200 mg/mL [to convert to nanomoles per liter, multiply by 5.476). A presumptive diagnosis of hemolytic-uremic syndrome led to a day of plasmapheresis, but then no schizocytes were found in the peripheral blood and results of the Coombs test were negative. Empirical antibiotic and antiviral treatment were started with ceftriaxone sodium, clarithromycin, and oseltamivir phosphate. Her blood and urine culture findings were negative. After 4 days of intensive care unit treatment, the patient progressively recovered and became hemodynamically stable. She no longer needed daily hemodialysis and she was being ventilated in spontaneous mode without sedative drugs. However, no awakening occurred. Neurological examination revealed a comatose patient with decorticated posturing after noxious stimuli, with normal brainstem functions and pupillary responses, without focal signs. Cranial computed tomography showed widespread cortical and deep brain hemorrhages (Figure, A and B). Brain magnetic resonance imaging and magnetic resonance angiography (Figure, C-G) revealed several foci of hemorrhages, internal jugular vein thrombosis, and thrombosis of multiple sinuses. Given the presence of cerebral venous thrombosis, a thorough search for autoimmune, prothrombotic, and infectious conditions was done. Serum human immunodeficiency virus; human T-lymphotropic virus; hepatitis A, B, and C; Venereal Disease Research Laboratory test; dengue and yellow fever; Rickettsial spotted fever; and leishmaniasis serologies were negative. An IgM immunoassay (enzyme-linked immunosorbent assay) for leptospirosis (Leptospira interrogans serovar icterohemorrhagiae) came out positive and was followed by microscopic agglutination test (MAT) titers of 1/400 at the first sample collected 5 days after the onset of symptoms. Another IgM enzyme-linked immunosorbent assay for leptospirosis performed 30 days after the onset of symptoms was still positive, with MAT titers of 1/100 for the serovar icterohemorrhagiae, lower than the initial values probably because a day of plasmapheresis was inadvertently performed before a hemolytic-uremic syndrome was ruled out. The final diagnosis was Weil syndrome complicated with cerebral venous thrombosis. The patient received low-molecular-weight heparin to treat the underlying prothrombotic state as well as ceftriaxone for 14 days. She was discharged from the intensive care unit without active interaction and without following commands, but her eyes had spontaneous opening. A cranial computed tomography scan was repeated 12 days after anticoagulation and showed a reduction of parenchymal edema and all hemorrhagic lesions. She was discharged from the hospital after 45 days with gastrostomy, tracheostomy, and an anticoagulation scheme. She started to follow simple commands but remained with anarthria and spastic tetraparesis.

Figures in this Article


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Cranial Computed Tomography (CT) and Brain Magnetic Resonance Imaging (MRI) and Magnetic Resonance Angiography (MRA)

A, Nonenhanced cranial CT showing bilateral temporal-parietal hemorrhages. B, Nonenhanced cranial CT showing multiple foci of hemorrhage, predominantly on the occipital lobes, left frontoparietal cortex, and corpus callosum. C, T1-weighted brain MRI showing diffuse hyperintensive signals with a bilateral occipital and frontal predominance. The corpus callosum and left internal capsule were also affected. D, Gradient-echo brain MRI showing multiple foci of hemorrhage in either the cortex and subcortical regions. E, Sagittal brain MRI showing a hyperintense signal in the frontal lobe, genu of the corpus callosum, and parietal cortex. F, Sagittal brain MRA showing absence of flow in the inferior sagittal sinus. G, Coronal brain MRA showing absence of flow in the right internal jugular vein and in the thrombosed right transverse and sigmoid sinuses.

Graphic Jump Location




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Collections