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Case Report/Case Series |

Unusual Case of Bilateral Caudate Infarcts Following Pituitary Apoplexy FREE

Tania Rebeiz, MD1; Wilson Cueva, MD1; Agnieszka Ardelt, MD, PhD1
[+] Author Affiliations
1Department of Neurology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois
JAMA Neurol. 2014;71(2):226-227. doi:10.1001/jamaneurol.2013.4528.
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Published online

Importance  Cerebral ischemia due to pituitary apoplexy is very rare. It may be caused by vasospasm or direct compression of cerebral vessels by the expanding mass. Bilateral caudate infarcts also are very rare. To our knowledge, this is the first case report that presents pituitary apoplexy causing compression of bilateral anterior cerebral artery branches and leading to bilateral caudate infarcts.

Observations  An 81-year-old woman with a pituitary macroadenoma presented with circulatory shock due to pituitary apoplexy. Neurological examination revealed new asymmetric quadriparesis with chronic bilateral visual disturbance. On brain magnetic resonance imaging, she was found to have watershed infarcts in the anterior cerebral artery–middle cerebral artery and middle cerebral artery–posterior cerebral artery watershed zones in addition to bilateral caudate infarcts.

Conclusions and Relevance  Pituitary apoplexy can cause compression of bilateral anterior cerebral arteries from the expanding mass and lead to bilateral caudate infarcts. It is important to understand the pathophysiology of cerebral ischemia in pituitary apoplexy to improve management.

Figures in this Article

Pituitary apoplexy can be a fatal condition. It rarely causes cerebral ischemia through compression or vasospasm. We report a case of pituitary apoplexy causing compression of bilateral anterior cerebral arteries and leading to bilateral caudate infarcts.

An 81-year-old woman known to have hypertension and a pituitary macroadenoma compressing the prechiasmatic optic nerves and causing significant bilateral blindness presented with stupor and generalized weakness. On the day of presentation, she had significant weakness and was not able to stand. She was brought to the emergency department and was found to be stuporous, hypotensive, and in shock, with the lowest recorded systolic blood pressure of 76 mm Hg. She was subsequently resuscitated with intravenous fluids, supported with 4 intravenous pressors, and endotracheally intubated. Neurological examination revealed a stuporous woman, not opening her eyes or following commands but with intact brainstem reflexes. She had an asymmetric quadriparesis with left hemibody weakness greater than right, left-sided spasticity and hyperreflexia, and upturning toes bilaterally. Brain magnetic resonance imaging showed a sella-based mass with intrinsic hemorrhage (Figure, A) and infarcts in the anterior cerebral artery (ACA)–middle cerebral artery (MCA) and MCA–posterior cerebral artery (PCA) watershed zones (Figure, B). Brain magnetic resonance angiography showed anterior displacement of bilateral ACAs and anterior communicating artery with patency of the distal ACAs (Figure, C). Diffusion-weighted imaging additionally showed bilateral caudate infarcts (Figure, D). During her hospitalization, her condition did not improve and her family decided to transition her to comfort care measures.

Place holder to copy figure label and caption
Figure.
Pituitary Apoplexy Causing Compression of the Anterior Cerebral Vasculature and Leading to Cerebral Ischemia

A, Axial, gradient-echo magnetic resonance image of the brain showing hemorrhage within the sellar mass (arrowhead). B, Axial diffusion-weighted magnetic resonance image of the brain showing infarcts in the anterior cerebral artery–middle cerebral artery watershed zones. C, Axial magnetic resonance image of the brain showing a sellar-based mass anteriorly displacing the bilateral anterior cerebral arteries (arrowheads). D, Axial diffusion-weighted magnetic resonance image of the brain showing infarcts in the bilateral caudate nuclei.

Graphic Jump Location

Pituitary tumor apoplexy is an acute clinical syndrome caused by either hemorrhage or infarction of the pituitary gland, leading to mass effect on surrounding structures causing altered mental status, headache, disturbed vision, and pituitary dysfunction.1 Only a few case reports in the literature describe cerebral ischemia due to pituitary apoplexy.2 Two mechanisms have been postulated for pituitary apoplexy–related cerebral ischemia: cerebral vasospasm and mechanical compression of the circle of Willis by the expanding mass.3 Anterior circulation hypoperfusion and ischemia could be secondary to chronic compression of the ACAs from the encasing pituitary tumor in the setting of sustained systemic hypotension from acute secondary adrenal insufficiency. In addition, pituitary apoplexy can also cause a sudden increase in local pituitary pressure to a median of 47 mm Hg,4 which in our case could have further potentiated the mass effect from this tumor on the ACAs. Sudden hemorrhage within the pituitary tumor led to pituitary apoplexy, which caused systemic hypotension and in turn led to watershed infarcts in the ACA-MCA and MCA-PCA zones. With respect to the bilateral caudate nucleus infarcts, the blood supply to the head of the caudate is variable. Most reports show that the caudate nuclei receive dual blood supply from the MCA and ACA; however, they can also be solely supplied by the ACA or the MCA.5 Our patient may have had compression of bilateral Heubner arteries, which are most commonly branches of the ACAs that run along the A1 segments and supply the heads of the caudate nuclei.6 Compression of the MCAs is unlikely to have been the culprit given that there is no evidence of other MCA territory infarcts. Internal carotid artery compression, which has frequently been reported in the literature in association with pituitary apoplexy,2 should also have caused more extensive infarcts. Another possible mechanism of bilateral caudate nucleus infarcts in our patient is compression of the first branch of the ACA (A1 segment) by the mass on one side and congenital absence of the A1 segment on the other side,7 a scenario that could not be ruled out on magnetic resonance angiography. In summary, to our knowledge, this is the first case report in the literature that describes pituitary apoplexy leading to bilateral caudate infarcts.

Corresponding Author: Tania Rebeiz, MD, Department of Neurology, Pritzker School of Medicine, University of Chicago, 40 E Delaware, Chicago, IL 60611 (tania.rebeiz@gmail.com).

Accepted for Publication: July 24, 2013.

Published Online: December 23, 2013. doi:10.1001/jamaneurol.2013.4528.

Author Contributions: Dr Rebeiz had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: All authors.

Acquisition of data: All authors.

Analysis and interpretation of data: Rebeiz, Ardelt.

Drafting of the manuscript: Rebeiz, Ardelt.

Critical revision of the manuscript for important intellectual content: All authors.

Study supervision: All authors.

Conflict of Interest Disclosures: None reported.

Nawar  RN, AbdelMannan  D, Selman  WR, Arafah  BM.  Pituitary tumor apoplexy: a review. J Intensive Care Med. 2008;23(2):75-90.
PubMed   |  Link to Article
Ahmed  SK, Semple  PL.  Cerebral ischaemia in pituitary apoplexy. Acta Neurochir (Wien). 2008;150(11):1193-1196, discussion 1196.
PubMed   |  Link to Article
Mohindra  S, Kovai  P, Chhabra  R.  Fatal bilateral ACA territory infarcts after pituitary apoplexy: a case report and literature review. Skull Base. 2010;20(4):285-288.
PubMed   |  Link to Article
Zayour  DH, Selman  WR, Arafah  BM.  Extreme elevation of intrasellar pressure in patients with pituitary tumor apoplexy: relation to pituitary function. J Clin Endocrinol Metab. 2004;89(11):5649-5654.
PubMed   |  Link to Article
van der Zwan  A, Hillen  B.  Review of the variability of the territories of the major cerebral arteries. Stroke. 1991;22(8):1078-1084.
PubMed   |  Link to Article
Caplan  LR, Schmahmann  JD, Kase  CS,  et al.  Caudate infarcts. Arch Neurol. 1990;47(2):133-143.
PubMed   |  Link to Article
Fukuoka  T, Osawa  A, Ohe  Y, Deguchi  I, Maeshima  S, Tanahashi  N.  Bilateral caudate nucleus infarction associated with a missing A1 segment. J Stroke Cerebrovasc Dis. 2012;21(8):e11-e12.
PubMed

Figures

Place holder to copy figure label and caption
Figure.
Pituitary Apoplexy Causing Compression of the Anterior Cerebral Vasculature and Leading to Cerebral Ischemia

A, Axial, gradient-echo magnetic resonance image of the brain showing hemorrhage within the sellar mass (arrowhead). B, Axial diffusion-weighted magnetic resonance image of the brain showing infarcts in the anterior cerebral artery–middle cerebral artery watershed zones. C, Axial magnetic resonance image of the brain showing a sellar-based mass anteriorly displacing the bilateral anterior cerebral arteries (arrowheads). D, Axial diffusion-weighted magnetic resonance image of the brain showing infarcts in the bilateral caudate nuclei.

Graphic Jump Location

Tables

References

Nawar  RN, AbdelMannan  D, Selman  WR, Arafah  BM.  Pituitary tumor apoplexy: a review. J Intensive Care Med. 2008;23(2):75-90.
PubMed   |  Link to Article
Ahmed  SK, Semple  PL.  Cerebral ischaemia in pituitary apoplexy. Acta Neurochir (Wien). 2008;150(11):1193-1196, discussion 1196.
PubMed   |  Link to Article
Mohindra  S, Kovai  P, Chhabra  R.  Fatal bilateral ACA territory infarcts after pituitary apoplexy: a case report and literature review. Skull Base. 2010;20(4):285-288.
PubMed   |  Link to Article
Zayour  DH, Selman  WR, Arafah  BM.  Extreme elevation of intrasellar pressure in patients with pituitary tumor apoplexy: relation to pituitary function. J Clin Endocrinol Metab. 2004;89(11):5649-5654.
PubMed   |  Link to Article
van der Zwan  A, Hillen  B.  Review of the variability of the territories of the major cerebral arteries. Stroke. 1991;22(8):1078-1084.
PubMed   |  Link to Article
Caplan  LR, Schmahmann  JD, Kase  CS,  et al.  Caudate infarcts. Arch Neurol. 1990;47(2):133-143.
PubMed   |  Link to Article
Fukuoka  T, Osawa  A, Ohe  Y, Deguchi  I, Maeshima  S, Tanahashi  N.  Bilateral caudate nucleus infarction associated with a missing A1 segment. J Stroke Cerebrovasc Dis. 2012;21(8):e11-e12.
PubMed

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