Accepted for Publication: July 22, 2013.
Published Online: October 14, 2013. doi:10.1001/jamaneurol.2013.4408.
Study concept and design: Dorsey, Beck, Biglan, Shoulson.
Analysis and interpretation of data: All authors.
Drafting of the manuscript: Dorsey, Darwin.
Critical revision of the manuscript for important intellectual content: Beck, Nichols, Brocht, Biglan, Shoulson.
Statistical analysis: Beck, Brocht.
Obtained funding: Dorsey, Shoulson.
Administrative, technical, and material support: Darwin, Nichols.
Study supervision: Dorsey.
Conflict of Interest Disclosures: Dr Dorsey is a consultant to Amgen, Clintrex, Lundbeck, and Medtronic and receives research support from Lundbeck and Prana Biotechnology. Dr Beck receives research support from Prana Biotechnology. Dr Biglan is a consultant to Lundbeck and receives research support from Lundbeck. Dr Shoulson is a consultant to Auspex, Lundbeck, and Prana Biotechnology and receives research support from Lundbeck and the US Food and Drug Administration. No other conflicts were reported.
Funding/Support: This analysis was funded by Lundbeck. CHDI Foundation, Inc funded the COHORT study.
Role of the Sponsor: The sponsor of this analysis (Lundbeck) had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation or approval of the manuscript; and decision to submit the manuscript for publication. The sponsor did review the manuscript prior to submission.
Group Information: The Huntington Study Group COHORT Investigators include the following individuals: Steering Committee: Ira Shoulson (principal investigator), University of Rochester, Rochester, NY; James Gusella (co–principal investigator), Massachusetts General Hospital, Boston; Tatiana Foroud (co–principal investigator), Indiana University School of Medicine, Indianapolis; Daniel P. Van Kammen, CHDI Foundation Inc, Los Angeles, California. Publications and Data Use Committee: Tatiana Foroud (chair), Indiana University School of Medicine; Ray Dorsey (co-chair), Johns Hopkins University, Baltimore, Maryland; John Warner and Joseph Giuliano, CHDI Foundation Inc; Louise Vetter, Huntington Disease Society of America, New York, New York; Oksana Suchowersky, University of Calgary, Calgary, Alberta, Canada; Christopher Beck and David Oakes, University of Rochester. Participating investigators and coordinators: Frederick Marshall and Charlyne Hickey, University of Rochester; Karen Marder, Steven Frucht, Carol Moskowitz, Ronda Clouse, Paula Wasserman, Lisa Muratori, and Elan Louis, Columbia University Medical Center, New York; Kathleen Shannon and Jeana Jaglin, Rush University Medical Center, Chicago, Illinois; Joseph Jankovic and Alicia Palao, Baylor College of Medicine, Houston, Texas; Madaline Harrison, Robert Davis, and Susan Dietrich, University of Virginia, Charlottesville; Carlos Singer and Monica Quesada, University of Miami, Miami, Florida; Steven Hersch, Diana Rosas, Kaloyan Tanev, Keith Malarick, and Robert McInnis, Massachusetts General Hospital; Amy Colcher, University of Pennsylvania, Philadelphia; Juan Sanchez-Ramos, University of South Florida, Tampa; Sandra Kostyk and Nick Doucette, Ohio State University, Columbus; Jane Paulsen, Ergun Uc, Robert Rodnitzky, Anne Leserman, and Stacie Vik, University of Iowa, Des Moines; Joel Perlmutter, Samer Tabbal, Amy Schmidt, and Stacey Barton, Washington University, St Louis, Missouri; Christopher Ross, Ray Dorsey, Frederick Nucifora, and Claire Welsh, Johns Hopkins University; Richard Dubinsky, Hilary Dubinsky, and Janice Broyles, University of Kansas Medical Center, Kansas City; Oksana Suchowersky and Mary Lou Klimek, University of Calgary; Randi Jones, Claudia Testa, and Stewart Factor, Emory University School of Medicine, Atlanta, Georgia; Elaine Sperin and Claudia Testa, Emory University, Atlanta; Dana Jennings, Institute for Neurological Disorders, John Morgan Medical College of Georgia, Augusta; Donald Higgins and Eric Molho, Albany Medical College, Albany, New York; John Adams, The Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Samuel Frank, Marie Saint-Hilaire, and Melissa Diggin, Boston University, Boston; Sarah Furtado, University of Alberta, Edmonton, Alberta, Canada; Francis Walker, Christine O'Neill, and Vicki Hunt, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Kimberly Quaid and Melissa Wesson, Indiana University School of Medicine; S. Elizabeth Zauber and Melissa Wesson, Indiana University, Indianapolis; Mark LeDoux, University of Tennessee Health Science Center, Memphis; Lynn Raymond, Blair Leavitt, and Joji Decolongon, University of British Columbia, Vancouver, British Columbia, Canada; Susan Perlman, University of California, Los Angeles; Jody Corey-Bloom, Guerry Peavy, and Jodi Goldstein, University of California, San Diego; Rajeev Kumar, Vicki Segro, and Diane Erickson, Colorado Neurological Institute, Englewood; Elizabeth McCusker, Jane Griffith, and Clement Loy, Westmead Hospital, New South Wales, Australia; Vicki Wheelock, Terry Tempkin, and Amanda Martin, University of California, Davis; Martha Nance, Hennepin County Medical Center, Minneapolis, Minnesota; Un Kang, University of Chicago, Chicago; William Mallonee and Greg Suter, Hereditary Neurological Disease Center, Wichita, Kansas; Fred Revilla and Maureen Gartner, University of Cincinnati/Cincinnati Children's Hospital, Cincinnati, Ohio; Carolyn Drazinic and Mary Jane Fitzpatrick, University of Connecticut, Storrs; Michel Panisset, Hôtel-Dieu Hôpital–CHUM, Montreal, Quebec, Canada; Kevin Duff, University of Utah, Salt Lake City; Burton Scott, Duke University Medical Center, Durham, North Carolina; William Weiner and Bradley Robottom, University of Maryland School of Medicine, Baltimore; Edmond Chiu, Olga Yastrubetskaya, and Andrew Churchyard, St Vincent's Aged Mental Health Service, Melbourne, Australia; Timothy John Greenamyre and Nancy Lucarelli, University of Pittsburgh, Pittsburgh, Pennsylvania; Pinky Agarwal, Booth Gardner Parkinson's Care Center, Kirkland, Washington; Irina Antonijevic, CHDI Foundation, Inc; Jeanen DeLaRosa, University of Texas, Galveston; Peter Panegyres, Neurodegenerative Disorders Research, Western Australia, Australia; Allison Coleman, University of British Columbia, Vancouver. Biostatistics/coordination center: David Oakes, Christopher Beck, Suzanne Robertson, Dustina Holt, Ken Eaton, Patricia Lindsay, and Lisa Deuel, University of Rochester. DNA genotyping center: Marcy MacDonald, Center for Human Genetic Research, Massachusetts General Hospital.
Additional Information: Dr Beck conducted and is responsible for the data analysis.