Accepted for Publication: July 8, 2013.
Published Online: October 21, 2013. doi:10.1001/jamaneurol.2013.4258.
Study concept and design: Spira, Wu, Wong, Ferrucci, Resnick.
Acquisition of data: Simonsick, Zhou, Wong, Resnick.
Analysis and interpretation of data: Spira, Gamaldo, An, Bilgel, Zhou, Wong, Resnick.
Drafting of the manuscript: Spira, An, Wu, Zhou.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Spira, An, Zhou.
Obtained funding: Wu, Ferrucci, Resnick.
Administrative, technical, and material support: Gamaldo, Simonsick, Zhou, Wong, Resnick.
Study supervision: Spira, Resnick.
Conflict of Interest Disclosures: Dr Wong has received contracts from Avid through The Johns Hopkins University. No other disclosures were reported.
Funding/Support: This study was supported in part by the Intramural Research Program, National Institute on Aging (NIA), National Institutes of Health (NIH); by Research and Development Contract HHSN-260-2004-00012C, NIA; by a Synapses, Circuits and Cognitive Disorders Award from The Johns Hopkins School of Medicine Brain Science Institute; by Mentored Research Scientist Development Award 1K01AG033195 from the NIA (Dr Spira); and by career award K24 DA000412 from the NIH, National Institute on Drug Abuse (Dr Wong, 2000-2011).
Role of the Sponsor: Investigators from the NIA Intramural Research Program were involved in all aspects of this manuscript. The NIA Extramural Research Program, the National Institute on Drug Abuse, and The Johns Hopkins School of Medicine Brain Science Institute had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Previous Presentations: Results from this study were presented at the 2013 Annual Meeting of the American Association for Geriatric Psychiatry; March 16, 2013; Los Angeles, California; and the 27th Annual Meeting of the Associated Professional Sleep Societies; June 3, 2013; Baltimore, Maryland.