Accepted for Publication: June 24, 2013.
Published Online: October 28, 2013. doi:10.1001/jamaneurol.2013.4013.
Study concept and design: Wirth, Rabinovici, Jagust.
Analysis and interpretation of data: Wirth, Villeneuve, Madison, Oh, Haase, Landau.
Drafting of the manuscript: Wirth, Madison, Oh, Jagust.
Critical revision of the manuscript for important intellectual content: Wirth, Villeneuve, Haase, Landau, Rabinovici, Jagust.
Statistical analysis: Wirth, Villeneuve, Haase.
Obtained funding: Wirth, Jagust.
Study supervision: Jagust.
Conflict of Interest Disclosures: Dr Landau has consulted for Avid Radiopharmaceuticals, Biogen, Synarc, and Janssen AI. Dr Rabinovici receives research support from Avid Radiopharmaceuticals and has consulted for Eli Lilly. Dr Jagust has served as a consultant to Genentech, Synarc, and Janssen Alzheimer Immunotherapy. He receives research support from the National Institutes of Health. No other disclosures were reported.
Funding/Support: This research was also supported by National Institutes of Health grants P30-AG010129, K01-AG030514, AG034570, K23-AG031861, P01-AG1972403, and P50-AG023501, Alzheimer’s Association grant NIRG-07-59422, the John Douglas French Alzheimer’s Foundation, State of California Department of Health Services Alzheimer’s Disease Research Center of California grant 04-33516, and Swiss National Science Foundation grant PA00P1-131515.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We sincerely thank the following contributors: Suzanne Baker, PhD (University of California [UC], Berkeley, neuroimage analysis support), Grace Tang (UC Berkeley, neuroimage analysis support), Pia Ghosh (Memory and Aging Center, University of California, San Francisco, neuroimage analysis support), and Jacob Vogel (UC Berkeley, manuscript drafting) and Renaud La Joie, PhD (UC Berkeley, result discussion).