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Comment & Response |

Next-Generation Phenotyping and Genomic Incidental Findings—Reply

Meike Kasten, MD1,2; Anne Grünewald, PhD1; Christine Klein, MD1
[+] Author Affiliations
1Institute of Neurogenetics, University of Lübeck, Lübeck, Germany
2Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany
JAMA Neurol. 2013;70(12):1590-1591. doi:10.1001/jamaneurol.2013.4812.
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In Reply We thank the authors for their appraisal of our recent article and wish to expand on a few aspects.

An important point raised by Canevelli and Blasimme is that of incidental findings, which are currently being generated in genome analyses without a clear perspective on how to implement them in clinical practice and patient counseling.1 Further illustrating the need to catch up with genetics2 is recent progress in pooled data analyses. For example, comprehensive online tools are available to view and (meta-)analyze available genetic data on Parkinson disease and Alzheimer disease (http://www.pdgene.org/ and http://www.alzgene.org). However, to make optimal use of this resource and to use it in clinical practice, we need to connect genetic and clinical information.


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December 1, 2013
Marco Canevelli, MD; Alessandro Blasimme, MA, PhD
1Department of Neurology and Psychiatry, Memory Clinic, University Sapienza, Rome, Italy
2INSERM UMR 1027, Université de Toulouse III, Paul Sabatier, Faculté de Médicine, Toulouse, France
JAMA Neurol. 2013;70(12):1589. doi:10.1001/jamaneurol.2013.4521.
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