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In This Issue of JAMA Neurology |

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JAMA Neurol. 2013;70(12):1465-1467. doi:10.1001/jamaneurol.2013.2897.
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RESEARCH

Chatterjee and colleagues perform a systematic review and meta-analysis to quantitatively assess the rates of intracranial hemorrhage within the framework of both conventional and Bayesian statistics.

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Gonzaga-Jauregui and coauthors elucidate the molecular cause of a complex neuropathy phenotype in 3 patients by applying genomic sequencing strategies.

Hocker et al develop a model to differentiate central from infectious fever in critically ill neurologic patients with fever of an undetermined cause.

Su and colleagues identify biomarkers in the plasma and cerebrospinal fluid of patients with amyotrophic lateral sclerosis that can predict prognosis.

Wirth and coauthors examine relationships between β-amyloid and non–β-amyloid factors and neurodegeneration within Alzheimer disease (AD) regions in cognitively normal older adults.

Dorsey et al determine the longitudinal change in clinical features among individuals with Huntington disease compared with controls.

Clardy and colleagues conduct a medical record review and serological evaluation to describe patients with disorders in the stiff-man syndrome spectrum beginning in childhood.

Spira and coauthors examine the association between self-reported sleep variables and β-amyloid deposition in community-dwelling older adults.

Lim et al determine whether better sleep consolidation attenuates the relationship of the APOE genotype to the risk of incident Alzheimer disease (AD) and the burden of AD pathology in a long-term follow-up study of community-dwelling elderly individuals without dementia.

Mitochondrial DNA (mtDNA) disorders have emerged as major causes of inherited neurologic disease. Spyropoulos and coauthors provide a case report describing monozygotic male twins with ptosis, optic atrophy, and recent-onset intractable myoclonic epilepsy.

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CLINICAL REVIEW & EDUCATION

Zipp and colleagues note that although multiple sclerosis (MS) has long been considered a primarily inflammatory, demyelinating disease of the central nervous system, modern histopathology and imaging techniques show that neurodegenerative processes also have a definitive role in MS pathology. They review reports from the last decade and outline clinical results on the topic.

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