Accepted for Publication: August 14, 2013.
Published Online: November 25, 2013. doi:10.1001/jamaneurol.2013.4781.
Study concept and design: Weinstein, Beiser, Wolf, DeStefano, Vasan, Seshadri.
Acquisition of data: Weinstein, Beiser, Chen, Vorgias, Au, Pikula, Wolf, Seshadri.
Analysis and interpretation of data: Weinstein, Beiser, Choi, Preis, Chen, Seshadri.
Drafting of the manuscript: Weinstein, Seshadri.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Beiser, Choi, Preis, DeStefano.
Obtained funding: Wolf, Seshadri.
Administrative, technical, or material support: Chen, Vorgias, Vasan.
Study supervision: Chen, Seshadri.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work received support from the National Heart, Lung and Blood Institute’s Framingham Heart Study (contract no. N01-HC-25195) and grants from the National Institute of Neurological Disorders and Stroke (NS17950); the National Heart, Lung and Blood Association (HL93029, U01HL 096917); and the National Institute of Aging (AG08122, AG16495, AG033193, AG031287, and P30AG013846).
Role of the Sponsor: The funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke; the National Heart, Lung and Blood Institute; the National Institute of Aging; or the National Institutes of Health.
Additional Contributions: This work was supported by the dedication of the Framingham Heart Study participants.