Accepted for Publication: August 22, 2013.
Published Online: November 18, 2013. doi:10.1001/jamaneurol.2013.4888.
Study concept and design: Paradas, Akman.
Acquisition of data: Paradas, Akman.
Analysis and interpretation of data: Paradas, Akman.
Drafting of the manuscript: Paradas, Akman.
Critical revision of the manuscript for important intellectual content: Hirano, DiMauro.
Obtained funding: Akman.
Administrative, technical, and material support: Ionete, Lau, Riskind, Jones, Smith, Hirano, DiMauro.
Conflict of Interest Disclosures: Dr Ionete has received research support from Genzyme Corporation and Biogen Idec. Dr Lau has received research support from Genzyme Corporation, Biomarin, Shire, Amicus, and GlaxoSmithKline and has received compensation as a consultant to Pfizer. Dr Riskind has consulted for Genzyme Corporation and has received research support from Genzyme Corporation, Biogen Idec, sanofi-aventis, Roche, Genentech, Novartis, Teva Pharmaceuticals Industries LTD, Bayer, ACP, and EMD Serono. Dr Hirano has received honoraria as a member of the Athena Diagnostic Speakers’ Bureau. Dr Jones received research support from Biogen Idec, Genzyme Corporation, and Novartis; consulting compensation from Biogen Idec, Genzyme Corporation, and EMD Serono; and speaking honoraria from Biogen Idec, Novartis, EMD Serono, and Teva Pharmaceuticals Industries LTD. Dr DiMauro receives compensation as a member of the editorial board of MedLink Neurology. No other disclosures were reported.
Funding/Support: This research was supported by fellowship BA12/0097 from the Spanish Government, Instituto de Salud Carlos III, Ministerio de Economia y Competitividad, Madrid, Spain (Dr Paradas); by the Adult Polyglucosan Body Disease Research Foundation (Dr Akman); and by the Muscular Dystrophy Association (Dr Akman).
Role of the Sponsor: The Adult Polyglucosan Body Disease Research Foundation, the Muscular Dystrophy Association, and the Spanish Government had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, and approval of the manuscript; and decision to submit the manuscript for publication.