Accepted for Publication: August 22, 2013.
Published Online: November 18, 2013. doi:10.1001/jamaneurol.2013.4857.
Study concept and design: Grau-Rivera, Sánchez-Valle, Dalmau, Graus.
Acquisition of data: Grau-Rivera, Sánchez-Valle, Saiz, Bernabé, Munteis, Pujadas, Salvador, Saura, Ugarte, Titulaer.
Analysis and interpretation of data: Grau-Rivera, Sánchez-Valle, Saiz, Molinuevo, Titulaer, Dalmau, Graus.
Drafting of the manuscript: Grau-Rivera, Graus.
Critical revision of the manuscript for important intellectual content: All authors.
Obtained funding: Dalmau, Graus.
Administrative, technical, and material support: Graus.
Study supervision: Dalmau, Graus.
Conflict of Interest Disclosures: Dr Dalmau has received a research grant from Euroimmun and receives royalties from patents for the use of Ma2 and NMDAR as autoantibody tests. No other disclosures are reported.
Funding/Support: This work was supported by National Institutes of Health grants RO1NS077851, RO1MH094741, and FIS PI11/01780 and by Fundació la Marató TV3 (Dr Dalmau) and an Erasmus Medical Center fellowship (Dr Titulaer).
Role of the Sponsor: The National Institutes of Health and Fundació la Marató TV3 had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Ellen Gelpí, MD, of the Neurological Tissue Bank of the Biobanc-IDIBAPS, performed detailed neuropathologic studies; Carlos Nos, MD, from the CJD surveillance center of Generalitat de Catalunya, helped in the identification of CJD cases; Myrna Rosenfeld, MD, reviewed the manuscript; and Mercè Alba, Bsc, and Eva Caballero, Bsc, provided excellent technical support. No contributor received financial compensation. We thank all physicians who have contributed by providing clinical information on their patients and all patients for their generous contribution to research.