Accepted for Publication: August 21, 2013.
Published Online: November 11, 2013. doi:10.1001/jamaneurol.2013.4847.
Study concept and design: Hong, Hutchinson, Aigbirhio, Coles, Baron, Pickard, Fryer, Stewart, Menon.
Acquisition of data: Veenith, Dewar, Outtrim, Mani, Williams, Pimlott, Tavares, Canales, Aigbirhio, Coles, Baron, Pickard, Fryer, Stewart, Menon.
Analysis and interpretation of data: Hong, Veenith, Dewar, Pimlott, Tavares, Canales, Mathis, Klunk, Fryer, Stewart, Menon.
Drafting of the manuscript: Hong, Fryer, Stewart, Menon.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Hong, Menon.
Obtained funding: Baron, Pickard, Menon.
Administrative, technical, or material support: Dewar, Outtrim, Pimlott, Tavares, Canales, Coles, Menon.
Study supervision: Hutchinson, Aigbirhio, Coles, Baron, Pickard, Menon.
Conflict of Interest Disclosures: GE Healthcare holds a license agreement with the University of Pittsburgh based on the PiB technology described in this article. Drs Klunk and Mathis are coinventors of PiB and, as such, have a financial interest in this license agreement. No other disclosures were reported.
Funding/Support: This study was supported by the Neuroscience Theme of the National Institute for Health Research Cambridge Biomedical Research Centre. Drs Menon and Pickard are supported by National Institute for Health Research Senior Investigator awards. Dr Hutchinson is supported by funding from the Academy of Medical Sciences. Radiochemistry development of [11C]PiB was supported by grant RG46503 from the Medical Research Council (United Kingdom). Data collection in controls was undertaken by funding awarded to Dr Baron by the National Institute for Health Research Cambridge Biomedical Research Centre. Dr Klunk is supported by the following grants: P50 AG005133, R37 AG025516, P01 AG025204.
Role of the Sponsor: GE Healthcare provided no grant support for this study and had no role in the design or interpretation of the results or in the preparation of the manuscript.