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Comment & Response |

Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids and Fatal B-Cell Lymphoma

Hongliang Zhang, MD, PhD1; Jiang Wu, MD, PhD1
[+] Author Affiliations
1Department of Neurology, First Hospital of Jilin University, Changchun, China
JAMA Neurol. 2013;70(11):1459. doi:10.1001/jamaneurol.2013.4074.
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To the Editor De Graaff and colleagues1 described a 57-year-old male patient who initially presented with clinical, radiologic, and pathologic features of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) and had an unfavorable outcome. This is an interesting case because it remains an enigma whether CLIPPERS is an isolated disease or a syndrome including different overlapping diseases and their prestages.


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November 1, 2013
Hjalmar J. De Graaff, BSc; Mike P. Wattjes, MD, PhD; Annemieke J. Rozemuller, MD, PhD; Axel Petzold, MD, PhD; Joep Killestein, MD, PhD
1MS Center Amsterdam, Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands
2MS Center Amsterdam, Department of Radiology, VU University Medical Center, Amsterdam, the Netherlands
3Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands.
JAMA Neurol. 2013;70(11):1459-1460. doi:10.1001/jamaneurol.2013.4757.
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