Study concept and design: Khoury, Koralnik.
Acquisition of data: Khoury, Koralnik.
Analysis and interpretation of data: All authors.
Drafting of the manuscript: Khoury, Koralnik.
Critical revision of the manuscript for important intellectual content: Mittleman.
Statistical analysis: Khoury, Mittleman.
Administrative, technical, or material support: Koralnik.
Study supervision: Koralnik.
Conflict of Interest Disclosures: Dr Koralnik has received a research grant from Biogen Idec and the National Multiple Sclerosis Society; served on scientific advisory boards for Hoffmann-LaRoche, GlaxoSmithKline, and Merck Serono; and received consulting fees from Bristol-Myers Squibb, Ono Pharmaceuticals, Merck Serono, Hoffmann-LaRoche, Perseid Therapeutics, Vertex Pharmaceutical, and Johnson & Johnson. No other disclosures were reported.
Funding/Support: This work was supported in part by grant BU-CHART/NIH T32 AI052074 from the National Institute of Allergy and Infectious Diseases to Dr Khoury and grants R01 NS 074995 and 047029 and K24 NS 060950 from the National Institutes of Health to Dr Koralnik. This work was conducted with support from Harvard Catalyst/The Harvard Clinical and Translational Science Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health Award 8UL1TR000170-05, and financial contributions from Harvard University and its affiliated academic health care centers) in the management, analysis, and interpretation of the data.
Role of the Sponsors: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard Catalyst, Harvard University and its affiliated academic health care centers, or the National Institutes of Health.