Accepted for Publication: April 23, 2013.
Published Online: August 19, 2013. doi:10.1001/jamaneurol.2013.3258.
Acquisition of data: Pollock, Chow.
Analysis and interpretation of data: Day, Farb, Tang-Wai, Masellis, Black, Freedman, Chow.
Drafting of the manuscript: Day, Farb, Chow.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Day, Farb.
Obtained funding: Farb, Freedman, Chow.
Administrative, technical, and material support: Chow.
Study supervision: Tang-Wai, Chow.
Conflict of Interest Disclosures: Dr Tang-Wai holds a grant with the Weston Foundation and is a collaborator on grants from the Canadian Institutes of Health Research, Alzheimer Society of Canada, Parkinson Society of Canada, and The Michael J. Fox Foundation for Parkinson’s Research. Dr Masellis has received speaker honoraria from Novartis and EMD Serono, Inc; serves as an associate editor for Current Pharmacogenomics and Personalized Medicine; receives publishing royalties from Henry Stewart Talks; has served as a consultant for Bioscape Medical Imaging CRO; and receives research support from the Canadian Institutes of Health Research, Parkinson Society Canada; an Early Researcher Award from the Ministry of Economic Development and Innovation of Ontario, The Consortium of Canadian Centres for Clinical Cognitive Research, and Teva Pharmaceutical Industries Ltd. Dr Black holds grants from the Weston Foundation, Brain Canada, Canadian Institutes of Health, Heart and Stroke Foundation, and Heart and Stroke Foundation Centre for Stroke Recovery, as well as research contracts with Roche, Pfizer, Elan, and Glaxo Smith Kline; she has served as an ad hoc consultant for Roche, Bristol-Myers Squibb, Pfizer, Novartis, and Elan and has presented continuing medical education sponsored by Pfizer, Eisai, and Novartis. Dr Freedman has served on an advisory board for Novartis, has consulted with Bristol-Myers Squibb, received financial support for a behavioral neurology fellow from Eli Lilly Canada, receives royalties for a book on clock drawing from Oxford University Press, and is listed on a provisional patent related to methods and kits for the differential diagnosis of Alzheimer disease vs frontotemporal dementia using blood biomarkers and may be listed on the planned patent application. Dr Chow received support for collection of the resting-state data used in this study from an investigator-initiated trial grant from Lundbeck Canada. No other disclosures were reported.
Funding/Support: This work was supported by grants from Women of Baycrest and the Moir Family (Drs Farb and Chow), the Sam and Ida Ross Memory Clinic (Drs Freedman and Chow), the Saul A. Silverman Family Foundation as a Canada International Scientific Exchange Program, and Morris Kerzner Memorial Fund (Dr Freedman), and through an investigator-initiated trial grant from Lundbeck Canada (Dr Chow).