Accepted for Publication: April 23, 2013.
Published Online: August 19, 2013. doi:10.1001/jamaneurol.2013.3253.
Acquisition of data: Fagan, Benzinger, Morris, Ances.
Analysis and interpretation of data: Wang, Brier, Snyder, Thomas, Xiong, Benzinger, Ances.
Drafting of the manuscript: Wang, Brier, Snyder, Holtzman, Ances.
Critical revision of the manuscript for important intellectual content: Wang, Snyder, Thomas, Fagan, Xiong, Benzinger, Holtzman, Morris, Ances.
Statistical analysis: Wang, Brier, Snyder, Thomas, Xiong.
Obtained funding: Benzinger, Morris, Ances.
Administrative, technical, and material support: Snyder, Thomas, Fagan, Benzinger, Holtzman, Ances.
Study supervision: Snyder, Benzinger, Holtzman, Ances.
Conflict of Interest Disclosures: Dr Fagan consults for Roche and Lilly USA. Dr Benzinger consults for Biomedical Systems, Inc and ICON Medical Imaging and receives research support from Avid Radiopharmaceuticals. Dr Holtzman reports consulting for Pfizer, Bristol-Myers Squibb, and Innogenetics and is on the scientific advisory boards of En Vivo, Satori, and C2N Diagnostics. Dr Morris has participated or is participating in clinical trials of antidementia drugs sponsored by Janssen Immunotherapy and by Pfizer; he has served as a consultant for Eisai, Esteve, Janssen Alzheimer Immunotherapy Program, Glaxo-Smith-Kline, Novartis, and Pfizer and receives research support from Eli Lilly/Avid Radiopharmaceuticals. No other disclosures were reported.
Funding/Support: This study was supported by grant NS06833 from the National Institute of Neurological Disorders and Stroke and by grant P30NS048056 from the National Institute of Mental Health (Dr Snyder); by grants R01AG034119, R01AG029672, and P01AG50837 from the National Institute on Aging (Dr Xiong); by the American Roentgen Ray Society Foundation (Dr Benzinger); by grants P01AG026276, P01AG03991, and P50 AG05681 (under which study participants were enrolled) and U19AG032438 from the National Institute on Aging (Dr Morris); by pilot grant 3255 ADRC 26 from The Charles F. and Joanne Knight Alzheimer’s Disease Research Center, by grant K23MH081786 from the National Institute of Mental Health, by grants R01NR012907, R01NR012657, and R01NR014449 from the National Institute of Nursing Research, and by the Alzheimer’s Association (Dr Ances).
Additional Contributions: The Charles F. and Joanne Knight Alzheimer’s Disease Research Center Clinical Core performed participant assessments, Biomarker Core assayed cerebrospinal fluid samples, and Genetics Core genotyped apolipoprotein E. We thank all of our research participants.