Study concept and design: Pomara, Frangione, Zlokovic.
Acquisition of data: Halliday, Pomara, Sagare.
Analysis and interpretation of data: Halliday, Mack, Zlokovic.
Drafting of the manuscript: Halliday, Zlokovic.
Critical revision of the manuscript for important intellectual content: Pomara, Sagare, Mack, Frangione, Zlokovic.
Statistical analysis: Halliday, Mack
Obtained funding: Pomara, Zlokovic.
Administrative, technical, or material support: Pomara
Study supervision: Pomara, Zlokovic.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported by grants R37NS34467 and R37AG23084 to Dr Zlokovic from the National Institutes of Health (NIH) and by grant R01MH-080405 to Dr Pomara from the NIH.
Additional Contributions: We thank Leslie Saint-Louis, MD, for performing lumbar punctures and Antero S. Sarreal, MD, and Raymundo T. Hernando, MD, for their assistance with patient recruitment.