Accepted for Publication: May 23, 2013.
Published Online: September 9, 2013. doi:10.1001/jamaneurol.2013.3646.
Study concept and design: Butcher, Kiehl, Bassett.
Acquisition of data: All authors.
Analysis and interpretation of data: All authors.
Drafting of the manuscript: Butcher, Bassett.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Butcher, Chow.
Obtained funding: Butcher, Rogaeva, Lang, Bassett.
Administrative, technical, or material support: Butcher, Kiehl, Hazrati, Rogaeva.
Study supervision: Bassett.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported by the Canadian Institutes of Health Research (Butcher and Bassett), the Canada Research Chairs Program (Bassett), the Ontario Research Fund (Rogaeva), and the National Parkinson Foundation (Lang).
Role of the Sponsors: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Additional Contributions: We thank the patients’ families who made this study possible, the pathologists who performed the general autopsies, and our colleagues for referring patients.