Submitted for Publication: February 28, 2013; accepted April 16, 2013.
Published Online: September 9, 2013. doi:10.1001/jamaneurol.2013.3185.
Acquisition of data: Paradas, Camaño, Otaegui, Oz, Emmanuele, Hirano.
Analysis and interpretation of data: Paradas, Emmanuele, DiMauro, Hirano.
Drafting of the manuscript: Paradas, Oz, Hirano.
Critical revision of the manuscript for important intellectual content: Camaño, Otaegui, Emmanuele, DiMauro, Hirano.
Administrative, technical, or material support: Camaño, Otaegui, Hirano.
Study supervision: DiMauro, Hirano.
Conflict of Interest Disclosures: DiMauro receives compensation as a member of the editorial board of MedLink Neurology. Hirano has received honoraria as a member of the Athena Diagnostics speakers’ bureau. No other disclosures were reported.
Funding/Support: This study was supported by grant HD32062 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, by grant U54NS078059 from the National Institute of Neurological Disorders and Stroke and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and by the Marriott Mitochondrial Disorder Clinical Research Fund. Hirano was supported by grants R01 HD057543 and R01 HD056103 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the Office of Dietary Supplements as well as by the Muscular Dystrophy Association. Paradas was supported by fellowship BA12/0097 from the Spanish government, Health Institute Carlos III, Ministerio de Economia y Competitividad.
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Previous Presentation: This study was presented as a poster at the 65th Annual Meeting of the American Academy of Neurology; March 21, 2013; San Diego, California.