Comment and Response |

Sleep Evaluation by Actigraphy for Patients With Alzheimer Disease

Tomoyuki Kawada, MD1
[+] Author Affiliations
1Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
JAMA Neurol. 2013;70(8):1074. doi:10.1001/jamaneurol.2013.3163.
Text Size: A A A
Published online


To the Editor Ju et al1 reported objective sleep for 142 patients (58 men and 84 women) with preclinical stage Alzheimer disease. The mean (SD) age of the patients was 65.6 (8.2) years old. Among them, 32 patients presented with β-amyloid 42 levels in cerebrospinal fluid of 500 pg/mL or less. The authors used wrist actigraph Actiwatch 2 (Philips Respironics), and sleep efficiency and total sleep time were used as the main sleep indicators. They concluded there was a significant decrease in sleep efficiency observed in the group with lower β-amyloid 42 levels. In contrast, there was no significant difference in the mean value of total sleep time between groups stratified by β-amyloid 42 level.


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





August 1, 2013
Yo-El S. Ju, MD; David M. Holtzman, MD
1Department of Neurology, Washington University School of Medicine, St Louis, Missouri
1Department of Neurology, Washington University School of Medicine, St Louis, Missouri2The Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St Louis, Missouri3Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri
JAMA Neurol. 2013;70(8):1074-1075. doi:10.1001/jamaneurol.2013.3490.
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Related Topics