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Comment and Response |

Sleep Evaluation by Actigraphy for Patients With Alzheimer Disease

Tomoyuki Kawada, MD1
[+] Author Affiliations
1Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
JAMA Neurol. 2013;70(8):1074. doi:10.1001/jamaneurol.2013.3163.
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To the Editor Ju et al1 reported objective sleep for 142 patients (58 men and 84 women) with preclinical stage Alzheimer disease. The mean (SD) age of the patients was 65.6 (8.2) years old. Among them, 32 patients presented with β-amyloid 42 levels in cerebrospinal fluid of 500 pg/mL or less. The authors used wrist actigraph Actiwatch 2 (Philips Respironics), and sleep efficiency and total sleep time were used as the main sleep indicators. They concluded there was a significant decrease in sleep efficiency observed in the group with lower β-amyloid 42 levels. In contrast, there was no significant difference in the mean value of total sleep time between groups stratified by β-amyloid 42 level.

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August 1, 2013
Yo-El S. Ju, MD; David M. Holtzman, MD
1Department of Neurology, Washington University School of Medicine, St Louis, Missouri
1Department of Neurology, Washington University School of Medicine, St Louis, Missouri2The Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St Louis, Missouri3Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri
JAMA Neurol. 2013;70(8):1074-1075. doi:10.1001/jamaneurol.2013.3490.
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