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In This Issue of JAMA Neurology |

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JAMA Neurol. 2013;70(8):955-957. doi:10.1001/jamaneurol.2013.2877.
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Hanson and colleagues characterize the lipidation states of β-amyloid peptides and apolipoprotein E in the cerebrospinal fluid in adults with respect to cognitive diagnosis and APOE ε4 allele carrier status at baseline and after a dietary intervention.

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Lewis and co-authors determine whether 4 g/d of ascorbic acid improves the neuropathy of subjects with Charcot-Marie-Tooth disease type 1A (CMT1A).

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To evaluate whether determinants of intracerebral hemorrhage (ICH) volume differ by topography, Falcone and colleagues sought to estimate location-specific effects for potential predictors of this radiological outcome.

Alkawadri and colleagues studied 14 consecutive cingulate gyrus epilepsy cases identified retrospectively to characterize the clinical and electrophysiological findings of epilepsies arising from the anterior and posterior cingulate gyrus.

In a retrospective study, Noe and coauthors evaluate noninvasive diagnostic test results and their association with excellent surgical outcomes (defined using Engel classes I-IIA of surgical outcomes) in a group of patients with medically resistant nonlesional extratemporal epilepsy.

In a case-control study, Foerster and coauthors determine whether there are reductions in γ-aminobutyric acid levels and elevations in glutamate-glutamine levels in selected brain regions of patients with amyotrophic lateral sclerosis (ALS) by use of proton magnetic resonance spectroscopy.

Hartung and colleagues investigate the role of interleukin 17F (IL-17F) in predicting treatment response to interferon beta-1b in patients with relapsing-remitting multiple sclerosis (MS) using the Singulex Erenna IL-17F immunoassay.

Wang and coauthors examine the associations of CGG repeat and FMR1 messenger RNA with motor-related fiber tracts in males with premutation alleles.

In a long-term study, Knopman et al evaluate 191 cognitively normal elderly individuals to determine the effect of the joint presence of β-amyloid and brain injury biomarkers on neurodegeneration.

Haight et al examine cerebrovascular disease and Alzheimer disease markers in relation to brain glucose metabolism in patients with mild cognitive impairment in a cohort study among the Alzheimer Disease Neuroimaging Initiative clinical sites in the United States and Canada.

Jochemsen and colleagues examined the associations of baseline blood pressure and change in blood pressure over time with progression of brain atrophy using data from the Secondary Manifestations of ARTerial disease–Magnetic Resonance Study.


Gokhale et al indicate that visual and somatosensory neglect have been extensively reported and widely recognized. Clinical assessment of auditory neglect is often difficult because of accompanying neurological deficits and lack of accurate bedside tests.





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