Published Online: July 8, 2013. doi:10.1001/jamaneurol.2013.136.
Acquisition of data: Vossel, Beagle, Rabinovici, Shu, Lee, Naasan, Hegde, Cornes, Henry, Nelson, Seeley, Geschwind, Gorno-Tempini, Shih, Miller.
Analysis and interpretation of data: Vossel, Beagle, Rabinovici, Shu, Lee, Naasan, Hegde, Henry, Nelson, Geschwind, Gorno-Tempini, Shih, Kirsch, Garcia, Miller, Mucke.
Drafting of the manuscript: Vossel, Beagle, Miller, Mucke.
Critical revision of the manuscript for important intellectual content: Vossel, Beagle, Rabinovici, Shu, Lee, Naasan, Hegde, Cornes, Henry, Nelson, Seeley, Geschwind, Gorno-Tempini, Shih, Kirsch, Garcia, Miller, Mucke.
Statistical analysis: Vossel.
Obtained funding: Vossel, Seeley, Miller, Mucke.
Administrative, technical, and material support: Beagle.
Study supervision: Miller, Mucke.
Conflict of Interest Disclosures: Dr Garcia receives research support from UCB Pharma and Medtronics Inc. Dr Mucke receives sponsored research support from Bristol-Myers Squibb and Takeda Pharmaceuticals.
Funding/Support: This study was supported by National Institutes of Health grants K23 AG038357 (Dr Vossel), K23 AG031861 (Dr Rabinovici), and P50 AG023501 and P01 AG19724 (Dr Miller), the John Douglas French Alzheimer’s Foundation (Drs Vossel and Rabinovici), a University of California, San Francisco Alzheimer’s Disease Research Center pilot project grant (Dr Vossel), and a gift from the S. D. Bechtel Jr Foundation (Dr Mucke).
Additional Contributions: We thank Jorge Palop, PhD, and Pascal Sanchez, PhD, for helpful comments on the manuscript; Kamalini Ranasinghe, MBBS, PhD, for assistance with medical record review; William Jagust, MD, for carbon 11–labeled Pittsburgh compound B positron emission tomography imaging; Anna Karydas, BA, for apoE genotyping; Anna Lisa Lucido, PhD, for editorial review; John C. W. Carroll for graphics support; and Monica Dela Cruz, BS, for administrative assistance.