Accepted for Publication: February 27, 2013.
Published Online: July 8, 2013. doi:10.1001/jamaneurol.2013.2815.
Study concept and design: Shulman, Chibnik, Bennett.
Acquisition of data: Shulman, McCabe, Patsopoulos, Corneveaux, Huentelman, Schneider, Reiman, Bennett.
Analysis and interpretation of data: Shulman, Chen, Keenan, Chibnik, Fleisher, Thiyyagura, Roontiva, Yu, Huentelman, Evans, De Jager, Bennett.
Drafting of the manuscript: Shulman, Keenan, Chibnik, De Jager.
Critical revision of the manuscript for important intellectual content: Shulman, Chen, Keenan, Chibnik, Fleisher, Thiyyagura, Roontiva, McCabe, Patsopoulos, Corneveaux, Yu, Huentelman, Evans, Schneider, Reiman, Bennett.
Statistical analysis: Shulman, Chen, Keenan, Chibnik, Thiyyagura, Roontiva, Corneveaux, Yu.
Obtained funding: Shulman, Huentelman, Evans, Reiman, Bennett.
Administrative, technical, and material support: McCabe, Patsopoulos, Huentelman, Schneider, Bennett.
Study supervision: Chen, Huentelman, Evans, Bennett.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work is supported by grants R01 AG30146, P30 AG10161, R01 AG17917, R01 AG15819, K08 AG034290, C06 RR029965, R01 AG11101, P30 AG19610, R01 AG023193, R01 NS059873, P50 AG16574, U01 AG016976, U24 NS051872, P50 AG23173, and K01 AG024079 from the National Institutes of Health and by the Illinois Department of Public Health, Kronos Life Sciences Laboratories, and the state of Arizona. Dr Shulman is additionally supported by a Career Award for Medical Scientists from the Burroughs Wellcome Fund. For additional funding information related to the ADNI, see http://dejager_lab.bwh.harvard.edu/wp-content/uploads/2013/02/Shulman-et-al-2013_-Online-1.pdf or https://www.radc.rush.edu/publications/2013/Shulman%20et%20al%202013_%20Online.pdf.
Online-Only Material: The eMethods, eTables, eFigures, and additional acknowledgments and references are available at http://dejager_lab.bwh.harvard.edu/wp-content/uploads/2013/02/Shulman-et-al-2013_-Online-1.pdf, http://dejager_lab.bwh.harvard.edu/wp-content/uploads/2013/02/Shulman-et-al.-2013_OnlineTables-21.xls, https://www.radc.rush.edu/publications/2013/Shulman%20et%20al%202013_%20Online.pdf, and https://www.radc.rush.edu/publications/2013/Shulman%20et%20al.%202013_OnlineTables.xls.
Additional Information: Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (http://adni.loni.ucla.edu). As such, the investigators within the ADNI contributed to the design and implementation of the ADNI and/or provided data but did not participate in analysis or writing of this article. A complete listing of ADNI investigators can be found at http://adni.loni.ucla.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf.
Additional Contributions: We are grateful to the participants in the Religious Orders Study, the Memory and Aging Project, the Arizona APOE Cohort, and ADNI.