Accepted for Publication: April 17, 2013.
Published Online: July 8, 2013. doi:10.1001/jamaneurol.2013.3197.
Study concept and design: Garone, Mootha.
Acquisition of data: Garone, Donati, Sacchini, Garcia-Diaz, Bruno, Calvo, Mootha.
Analysis and interpretation of data: Garone, Garcia-Diaz, Calvo, Mootha, DiMauro.
Drafting of the manuscript: Garone, Donati, Sacchini.
Critical revision of the manuscript for important intellectual content: Garcia-Diaz, Bruno, Calvo, Mootha, DiMauro.
Statistical analysis: Garone, Garcia-Diaz, Mootha.
Obtained funding: Mootha.
Administrative, technical, and material support: Mootha.
Study supervision: Mootha, DiMauro.
Conflict of Interest Disclosures: Dr DiMauro receives compensation as a member of the editorial board of MedLink Neurology.
Funding/Support: This work has been supported by the National Institutes of Health (grant HD032062), the Italian Congenital Metabolic Disorders Association, and the Marriott Mitochondrial Disorders Clinical Research Fund.