Group Information: A list of the
Alzheimer’s Disease Neuroimaging Initiative investigators appears at http://www.loni.ucla.edu/ADNI/Collaboration/ADNI_Authorship_list.pdf.
Accepted for Publication: November 20, 2012.
Published Online: June 17, 2013. doi:10.1001/jamaneurol.2013.1878.
Acquisition of data: Landau, Carmichael, and Jagust.
Analysis and interpretation of data: Haight, Landau, Schwarz, and DeCarli.
Drafting of the manuscript: Haight and Schwarz.
Critical revision of the manuscript for important intellectual content: Haight,
Landau, Carmichael, DeCarli, and Jagust.
Statistical analysis: Haight and Schwarz.
Obtained funding: DeCarli and Jagust.
Administrative, technical, and material support: Landau, DeCarli, and Jagust.
Study supervision: Jagust.
Conflict of Interest Disclosures: Dr Landau has
served on a scientific advisory board for Janssen Alzheimer Immunotherapy and as a neuroimaging
scientist at Avid Radiopharmaceuticals Inc. Dr Carmichael has received funding from the Dana
Foundation and the Hiblom Foundation, and his research has been supported by grant IIS-1117663 from
the National Science Foundation, by sponsor award 201016148-01 from the Department of Defense, and
by grants AG030514, AG010129, AG024904, AG20098, and AG012435 from the National Institutes of
Health. Dr DeCarli’s research is supported by grant AG 024904 from the National Institutes of
Health. Dr Jagust has served as a consultant to Genentech Inc, GE Healthcare, Bayer HealthCare,
Synarc, Janssen Alzheimer Immunotherapy, TauRx, Merck & Co, and Siemens, and his research has
been supported by grants AG027859, AG027984, and AG 024904 from the National Institutes of
Funding/Support: Data collection and sharing for
this project were funded by the ADNI (grant U01 AG024904
from the National Institutes of Health). ADNI is funded
by the National Institute on Aging and the
National Institute of Biomedical Imaging and
Bioengineering, as well as through generous contributions from the following:
Association, Alzheimer’s Drug Discovery
Foundation, Amorfix Life Sciences Ltd,
HealthCare, BioClinica Inc,
Biogen Idec Inc, Bristol-Myers Squibb Company, Eisai
Inc, Elan Pharmaceuticals Inc,
Eli Lilly and Company, F.
Hoffmann-La Roche Ltd and its affiliated company Genentech Inc, GE Healthcare,
Innogenetics NV, Janssen
Alzheimer Immunotherapy, Johnson & Johnson
Pharmaceutical Research & Development LLC, Medpace
Inc, Merck & Co, Meso Scale Diagnostics LLC, Novartis
Pharmaceuticals Corporation, Pfizer
Inc, Servier, Synarc, and Takeda Pharmaceutical
Company. The Canadian Institutes of Health
Research is providing funds to support ADNI clinical sites in Canada. Private
sector contributions are facilitated by the Foundation for the National
Institutes of Health (http://www.fnih.org). The grantee organization is the
Northern California Institute for Research and
Education, and the study is coordinated by the Alzheimer’s Disease
Cooperative Study at the University of California, San Diego. ADNI data are disseminated by the
Laboratory of Neuro Imaging at the University of California, Los Angeles. This research was also
supported by grants P30 AG010129 and K01 AG030514 from the National
Institutes of Health and by the Dana
Additional Information: Data used in the preparation of this article were obtained
from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (http://www.loni.ucla.edu/ADNI). As
such, the investigators within ADNI contributed to the design and implementation of ADNI or provided
data but did not participate in the analysis or writing of this article.
Additional Contributions: Natalie L. Marchant, PhD, provided helpful discussion
about the study.