Accepted for Publication: January 22, 2013.
Published Online: June 3, 2013. doi:10.1001/jamaneurol.2013.192
Study concept and design: Hartung, Steinman, Comi, Filippi, Jeffery, Kappos,
Axtell, Knappertz, Bogumil, Croze, Sandbrink, and Pohl.
Acquisition of data: Hartung, Steinman, Goodin, Comi, Filippi, Jeffery, Kappos,
Croze, and Sandbrink.
Analysis and interpretation of data: Hartung, Steinman, Comi, Cook, Filippi,
O’Connor, Jeffery, Kappos, Knappertz, Bogumil, Schwenke, Croze, Sandbrink, and Pohl.
Drafting of the manuscript: Hartung, Steinman, Comi, Knappertz, and Croze.
Critical revision of the manuscript for important intellectual content:
Steinman, Goodin, Cook, Filippi, O’Connor, Jeffery, Kappos, Axtell, Knappertz, Bogumil,
Schwenke, Croze, Sandbrink, and Pohl.
Statistical analysis: Steinman, Knappertz, Schwenke, and Croze.
Obtained funding: Knappertz and Sandbrink.
Administrative, technical, and material support: Hartung, Steinman, Comi, Cook,
Filippi, Jeffery, Croze, and Sandbrink.
Study supervision: Hartung, Steinman, Comi, Jeffery, Knappertz, Bogumil, Croze,
Sandbrink, and Pohl.
Conflict of Interest Disclosures: Dr Hartung
received honoraria for consultancy and lectures with approval by the Rector of
Heinrich-Heine-Universität from Bayer Pharma, Biogen Idec, Genzyme, Hoffman–La Roche,
Merck Serono, Novartis Pharma, and Teva–sanofi-aventis. Dr Steinman has served as a consultant
for Bayer, Novartis, MedImmune, sanofi-aventis, Teva, and Biogen Idec. Dr Comi has received
honoraria for consultancy from Bayer, Novartis, Teva, sanofi-aventis, Merck Serono, Actelion, and
Genzyme and has received honoraria for invited lectures from Bayer, Novartis, Teva, sanofi-aventis,
Merck Serono, Biogen, Serono Symposia International Foundation, and Genzyme. Dr Cook has received
research support from Bayer HealthCare and consultation fees from Bayer HealthCare, Merck Serono,
Biogen Idec, Teva, and sanofi-aventis. Dr Filippi serves on scientific advisory boards for Teva and
Genmab, has received funding for travel from Bayer Schering Pharma, Biogen Idec, Genmab, Merck
Serono, and Teva; serves as a consultant to Bayer Schering Pharma, Biogen Idec, Genmab, Merck
Serono, Pepgen Corp, and Teva; serves on speakers’ bureaus for Bayer Schering Pharma, Biogen
Idec, Genmab, Merck Serono, and Teva; receives research support from Bayer Schering Pharma, Biogen
Idec, Genmab, Merck Serono, Teva, Fondazione Italiana Sclerosi Multipla, the Italian Ministry of
Health, and CurePSP; is editor in chief of Journal of Neurology; and serves on the
editorial boards of the American Journal of Neuroradiology, BMC
Musculoskeletal Disorders, Clinical Neurology and Neurosurgery,
Erciyes Medical Journal, Journal of Neuroimaging, Journal
of Neurovirology, Magnetic Resonance Imaging, Multiple
Sclerosis, Neurological Sciences, and Lancet Neurology.
Dr Jeffery has received honoraria for speaking and consulting from Bayer, Biogen Idec, Teva, Serono,
Pfizer, GlaxoSmithKline, Novartis, Acorda, Genzyme, and Questcor and has received research support
from Bayer, Biogen Idec, Teva, Serono, Pfizer, and Novartis. The University Hospital Basel as
employer of Dr Kappos has received and dedicated to research support fees for board membership,
consultancy, or speaking, or grants, in the last 3 years from Actelion, Advancell, Allozyne, Bayer,
Bayhill, Biogen Idec, BioMarin, CSL Behring, Eli Lilly, European Union, Genmab, GeNeuro, Gianni
Rubatto Foundation. Glenmark, Merck Serono, MediciNova, Mitsubishi Pharma, Novartis, Novartis
Research Foundation, Novonordisk, Peptimmune, Roche, Roche Research Foundation, Santhera,
sanofi-aventis, Swiss MS Society, Swiss National Research Foundation, Teva, UCB, and Wyeth. Dr
Sandbrink holds stocks and stock options in Bayer Pharma AG. Dr Pohl holds stock options in Bayer
Funding/Support: This work was supported by
Bayer Pharma AG, Berlin, Germany.
Role of the Sponsor: Bayer Pharma AG was involved in the design and conduct of the
study; collection, management, analysis, and interpretation of the data; and preparation, review,
and approval of the manuscript.
Additional Contributions: Editorial assistance for the development of the manuscript
was provided by S. Dougherty, AxioMed Communications, Inc, and was supported by Bayer Healthcare