Group Information: A list of the SITS investigators was published in Lancet. 2007;369(9558):275-282.
Accepted for Publication: February 6, 2013.
Published Online: May 20, 2013. doi:10.1001/jamaneurol.2013.406
Acquisition of data: All authors.
Analysis and interpretation of data: Ahmed, Kellert, Mikulik, Tatlisumak, Toni.
Drafting of the manuscript: Ahmed.
Critical revision of the manuscript for important intellectual content: Kellert, Lees, Mikulik, Tatlisumak, Toni.
Statistical analysis: Ahmed.
Obtained funding: Ahmed.
Administrative, technical, and material support: Tatlisumak.
Study supervision: Kellert, Lees, Mikulik, Toni.
Conflict of Interest Disclosures: Dr Ahmed is an employee of SITS International, which received a grant from Boehringer Ingelheim and Ferrer for the SITS-MOST/SITS-ISTR study with alteplase. Dr Lees has received fees and expenses from Boehringer Ingelheim for his role as chairman of the independent data and safety monitoring board of the ECASS III trial with alteplase and for related lectures. He has also received fees from Paion, Forest, and Lundbeck for the Desmoteplase in Acute Ischemic Stroke trials. His institution has received grant assistance toward administrative expenses for coordination of SITS in the United Kingdom. Dr Mikulik has received honoraria payments and travel support from Boehringer Ingelheim. Dr Tatlisumak has significant research contracts with Boehringer Ingelheim, sanofi-aventis, H. Lundbeck A/S, Mitsubishi Pharma, Schering Plough, Concentric Medical, PhotoThera, and BrainsGate. He has received a grant from Boehringer Ingelheim and served on the scientific advisory board of and as consultant for Boehringer Ingelheim, Mitsubishi Pharma, and BrainsGate. Dr Toni received consulting fees from Boehringer Ingelheim and lecture fees from Boehringer Ingelheim, sanofi-aventis, and Pfizer
Funding/Support: The SITS-ISTR is funded by Boehringer Ingelheim, Ferrer, the EU Public Health Executive Authority, a medical training and research fund from the Stockholm County Council and the Karolinska Institutet, the Fighting Stroke project supported by the Swedish Heart-Lung Foundation and Karolinska Institutet, the Friends of Karolinska Institutet in the United States, and Johanniterorden. Dr Mikulik has received research support from the European Regional Development Fund (Project FNUSA-ICRC [grant CZ.1.05/1.1.00/02.0123]).
Additional Information: The Uppsala Clinical Research Centre in Sweden developed, maintained, and upgraded the software for the SITS register in close collaboration with SITS investigators until September 2010. The current SITS registry is developed, maintained, and upgraded by Zitelab (Copenhagen, Denmark) in close collaboration with SITS investigators.
Additional Contributions: We thank all the SITS-ISTR investigators and their centers for their participation. We also thank all the patients who participated in the SITS-ISTR study.