Accepted for Publication: November 6, 2012.
Published Online: April 22, 2013. doi:10.1001/jamaneurol.2013.1707
Author Contributions:Study concept and design: Coutinho, Loureiro, Cruz, Barros, Neves, Serrano, and Silva. Acquisition of data: Coutinho, Loureiro, Cruz, Barros, Tuna, Barbot, Guimarães, Alonso, Silveira, Sequeiros, Neves, and Serrano. Analysis and interpretation of data: Coutinho, Ruano, Barros, Barbot, Guimarães, Alonso, Silveira, Sequeiros, and Silva. Critical revision of the manuscript for important intellectual content: All authors. Statistical analysis: Ruano and Silva. Obtained funding: Coutinho, Cruz, Alonso, and Silva. Administrative, technical, and material support: Ruano, Loureiro, Cruz, Barros, Tuna, Sequeiros, Neves, and Serrano. Study supervision: Coutinho, Cruz, Barbot, Silveira, Neves, and Serrano.
Conflict of Interest Disclosures: None reported.
Funding/Support: The study was supported in part by grants STRDA/C/SAU/277/92, PECS/C/SAU/219/95, POCTI/ESP/32643/99, and POCTI/SAU-ESP/59114/2004 from Fundaçã para a Ciência e a Tecnologia and the Regional and District Health Authorities. Dr Alonso is funded by Progr Ciência, Programa Potencial Human–Quadro de Referência Estraégica Nacional, cofunded by European Social Fund and Minstério da Ciência, Tecnologia e Ensino Superior.
Additional Contributions: During the survey, many neurologists and residents in neurology collaborated in the fieldwork. We thank them, in particular Esmeralda Lourenço, MD, Cristina Alves, MD, José Vale Santos, MD, and Paula Ribeiro, MD. We also thank our patients, their families, and their family and public health physicians for their collaboration. We also thank other colleagues and genetic testing laboratories: Michel Koenig, PhD, Institut Génétique Biologie Moléculaire Cellulaire, Strasbourg, France; Patricia Maciel, PhD, Universidade do Minho, Braga, Portugal; Giovanni Stevanin, PhD, Christel Depienne, PhD, Sylvie Forlani, PhD, Alexandra Durr, MD, PhD, and Alexis Brice, MD, PhD, Hôpital Pitié -Salpêtrière, Paris, France; and Filippo Santorelli, MD, PhD, Portale dell'Ospedale Bambin Gesù di Roma, Roma, Italy.