Accepted for Publication: November 21, 2012.
Published Online: April 15, 2013. doi:10.1001/jamaneurol.2013.1925
Author Contributions: Dr Sidransky had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Nalls, Mann, Hardy, Honig, Trojanowski, Wolfsberg, and Sidransky. Acquisition of data: Duran, Kurzawa-Akanbi, McKeith, Chinnery, Morris, Theuns, Crosiers, Cras, Engelborghs, De Deyn, Van Broeckhoven, Mann, Snowden, Halliwell, Davidson, Gibbons, Harris, Sheerin, Bras, Clark, Marder, Honig, Berg, Maetzler, Brockmann, Gasser, Novellino, Quattrone, Annesi, De Marco, Rogaeva, Masellis, Black, Bilbao, Ghetti, Nichols, Halliday, Lesage, Klebe, Durr, Duyckaerts, Brice, Giasson, Trojanowski, Landazabal, Knight, Singleton, Wolfsberg, and Sidransky. Analysis and interpretation of data: Nalls, Duran, Lopez, Theuns, Croziers, Van Broeckhoven, Pickering-Brown, Clark, Honig, Brockmann, Masellis, Foroud, Pankratz, Trojanowski, Hurtig, Tayebi, Keller, and Sidransky. Drafting of the manuscript: Nalls, Chinnery, Theuns, Van Broeckhoven, Mann, Pickering-Brown, Gibbons, Foroud, Klebe, Giasson, Trojanowski, Landazabal, and Sidransky. Critical revision of the manuscript for important intellectual content: Nalls, Duran, Lopez, Kurzawa-Akanbi, McKeith, Morris, Theuns, Crosiers, Cras, Engelborghs, Van Broeckhoven, Snowden, Pickering-Brown, Halliwell, Davidson, Harris, Sheerin, Bras, Hardy, Clark, Marder, Honig, Berg, Maetzler, Brockmann, Gasser, Novellino, Quattrone, Annesi, De Marco, Rogaeva, Masellis, Black, Bilbao, Ghetti, Nichols, Pankratz, Halliday, Lesage, Durr, Duyckaerts, Brice, Trojanowski, Hurtig, Tayebi, Knight, Keller, Singleton, Wolfsberg, and Sidransky. Statistical analysis: Nalls, Foroud, Trojanowski, Keller, and Sidransky. Obtained funding: McKeith, Chinnery, Theuns, De Deyn, Van Broeckhoven, Pickering-Brown, Hardy, Clark, Black, Nichols, Brice, Giasson, Tayebi, and Sidransky. Administrative, technical, and material support: Nalls, Lopez, Kurzawa-Akanbi, Morris, Theuns, Van Broeckhoven, Mann, Halliwell, Davidson, Gibbons, Harris, Sheerin, Bras, Clark, Honig, Berg, Maetzler, Gasser, Rogaeva, Ghetti, Pankratz, Lesage, Duyckaerts, Giasson, Landazabal, Knight, Wolfsberg, and Sidransky. Study supervision: Nalls, McKeith, Chinnery, Morris, Theuns, Van Broeckhoven, Pickering-Brown, Clark, Bilbao, Trojanowski, Singleton, and Sidransky.
Conflict of Interest Disclosures: Dr Crosiers reports receiving travel support from Abbott and Boehringer Ingelheim. Dr Brockmann reports receiving speaker honoraria from Deutsche Gesellschaft für klinische Neurophysiologie, GlaxoSmithKline, and Orion Corporation. Dr Berg reports receiving consultation fees from UCB Schwarz Pharma, Merz, and Novartis; payment for lectures from Teva, GSC, Lundbeck, and UCB Schwarz Pharma; and grant support from Janssen Pharmaceutica, Teva, Michael J. Fox Foundation, the Federal Ministry of Education and Research, Abbott, Boehringer, German Parkinson's Disease Association, and the Center for Integrative Neurosciences. Dr Gasser reports receiving consultation fees from Cefalon Pharma and Merck-Serono; lecture fees from Valeant Pharma, Merck-Serono, UCB-Pharma, and Boehringer; and grant support from Novartis Pharma, European Union, Helmholtz Association, and the Federal Ministry of Education and Research. Dr Maetzler reports receiving lecture fees from GlaxoSmithKline and grant support from the Robert Bosch Foundation. Dr Masellis reports receiving speaker honoraria from Novartis and EMD Serono, Inc; serving as an associate editor for Current Pharmacogenomics and Personalized Medicine; receiving publishing royalties from Henry Stewart Talks; serving as a consultant for Bioscape Medical Imaging CRO; and receiving research support from the Canadian Institutes of Health Research, Parkinson Society Canada, an Early Researcher Award from the Ministry of Economic Development and Innovation of Ontario, Teva Pharmaceutical Industries Ltd, and the Department of Medicine, Sunnybrook Health Sciences Centre. Dr Black reports receiving contract research funds to the Cognitive Neurology Research and Stroke Research Units from Roche, GlaxoSmithKline, Novartis, Myriad, Pfizer, sanofi-aventis, Boehringer Ingelheim, Lundbeck, Novo Nordisk, and AstraZeneca and honoraria from Janssen-Ortho, Novartis, Lundbeck, Pfizer, Eisai, Myriad, GlaxoSmithKline, Roche, Schering-Plough, Elan, Wyeth, and Bristol-Myers Squibb. Dr Ghetti reports receiving support from Elan and Bayer Schering Pharma AG. Dr Nichols reports receiving support from the National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH).
Funding/Support: Certain tissue for this study was provided by the Newcastle Brain Tissue Resource, which is funded in part by grant G1100540 from the UK Medical Research Council (MRC) and awards from the UK National Institute for Health Research (NIHR) Biomedical Research Centre in Ageing and Age Related Diseases and Biomedical Research Unit in Lewy Body Disease to the Newcastle upon Tyne Hospitals National Health Service Foundation Trust, and by a grant from the Alzheimer's Society and Alzheimer's Research Trust as part of the Brains for Dementia Research Project (Drs Kurzawa-Akanbi, McKeith, Chinnery, and Morris). The clinical sample collection was partly supported by Parkinson's Disease UK grant K-0901. Human brain tissue samples for DNA extraction were received from the Sydney Brain Bank, which has approval to collect and distribute human brain tissue for research studies by the Human Research Ethics Committee of the University of New South Wales under the Human Tissue Act 1983. The French project was supported by contract ANR-08-NEUR-004-01 from the National Research Agency in the ERA-NET NEURON framework, and the research leading to these results has received funding from the program Investissements d’avenir ANR-10-IAIHU-06. Some of the human brain tissue samples for DNA extraction were received from the Massachusetts Alzheimer Disease Research Center and the Harvard Brain Tissue Research Center. In addition, this study was supported by the UK Lewy Body Disease Society (Dr Kurzawa-Akanbi); by the UK Health Protection Agency (Dr Morris); by the Methusalem excellence program of the Flemish government, a Centre of Excellence grant from the University Research Fund of the University of Antwerp, the Research Foundation Flanders, the Agency for Innovation by Science and Technology Flanders, the Interuniversity Attraction Poles program of the Belgian Science Policy Office, the Foundation for Alzheimer Research Belgium, and the Belgian Parkinson Foundation (Drs Theuns, Crosiers, Cras, Engelborghs, De Deyn, and Van Broeckhoven); by Alzheimers Research UK and Alzheimer's Society through their funding of the Manchester Brain Bank under the Brains for Dementia Research initiative (Drs Mann, Snowden, and Pickering-Brown and Mss Halliwell, Davidson, Gibbons, and Harris); by the MRC and Wellcome Trust (Drs Mann and Pickering-Brown); by award WT089698 from the Wellcome Trust/MRC Joint Call in Neurodegeneration to the UK Parkinson's Disease Consortium whose members are from the Institute of Neurology, University College London, the University of Sheffield, and the MRC Protein Phosphorylation Unit at the University of Dundee (Drs Duran, Sheerin, Bras, and Hardy); by a postdoctoral fellowship from Alfonso Martin Escudero Foundation (Dr Duran); by the Reta Lilla Trust (Dr Hardy); by grants 5R01NS060113 (Dr Clark) and R56NS036630 (Dr Marder) from the National Institute of Neurological Disorders and Stroke, NIH; by grant P50AG08702 (Drs Honig and Clark) from the National Institute on Aging, NIH; by the Panasci Fund for Lewy Body Research (Dr Honig), Alzheimer Disease Drug Discovery Foundation (Dr Honig), and the Parkinson's Disease Foundation (Drs Clark and Dr Marder); by European Project on Mendelian Forms of Parkinson's Disease grant agreements 241791 and FP7/2007-2013 from the European Community's Seventh Framework Programme (Drs Brockmann and Gasser); by research fund grants from the Canadian Institutes of Health Research (Drs Rogaeva and Black); by a New Investigator Award from the Parkinson Society Canada (Dr Masellis); by grants 2R56NS037167 and 2P30AG010133 from the National Institute on Aging, NIH (Dr Ghetti); by fellowship 630434 and project support 1008307 from the National Health and Medical Research Council of Australia (Dr Halliday); by grants from the Agence Nationale pour la Recherche (Drs Lesage, Klebe, Durr, Duyckaerts, and Brice); by High Q (Dr Durr); by grant NS053488 from the National Institute of Neurological Disorders and Stroke (Dr Ghetti); by the Intramural Research Program of the National Human Genome Research Institute, NIH (Drs Lopez, Tayebi, Knight, Wolfsberg, and Sidransky and Ms Landazabal); and by National Institute on Aging project Z01 AG000949-02 from the Intramural Research Program of the NIH (Drs Nalls and Singleton and Ms Keller).
This article was corrected for errors on August 7, 2013.