Accepted for Publication: August 27, 2012.
Published Online: April 15, 2013. doi:10.1001/2013.jamaneurol.537
Author Contributions: Drs Harms and Cruchaga contributed equally to this work. Study concept and design: Harms, Mayeux, Goate, and Cruchaga. Acquisition of data: Harms, Cairns, B. Cooper, P. Cooper, Mayo, Carrell, Faber, Williamson, Bird, Diaz-Arrastia, Foroud, Graff-Radford, Mayeux, and Chakraverty. Analysis and interpretation of data: Harms, Benitez, Cairns, P. Cooper, Boeve, and Cruchaga. Drafting of the manuscript: Harms, Benitez, and Cruchaga. Critical revision of the manuscript for important intellectual content: Harms, Cairns, B. Cooper, P. Cooper, Mayo, Carrell, Faber, Williamson, Bird, Diaz-Arrastia, Foroud, Boeve, Graff-Radford, Mayeux, Chakraverty, Goate, and Cruchaga. Statistical analysis: Cruchaga. Obtained funding: Mayeux, Goate, and Cruchaga. Administrative, technical, and material support: Harms, Cairns, B. Cooper, P. Cooper, Mayo, Carrell, Faber, Williamson, Diaz-Arrastia, Boeve, Mayeux, and Chakraverty. Study supervision: Williamson, Diaz-Arrastia, and Foroud.
Conflict of Interest Disclosures: Dr Bird receives licensing fees from Athena Diagnostics Inc. Dr Boeve has served as an investigator for clinical trials sponsored by Cephalon Inc, Allon Pharmaceuticals, and GE Healthcare. He receives royalties from the publication of a book titled Behavioral Neurology of Dementia (Cambridge Medicine, 2009). He has received honoraria from the American Academy of Neurology, and he receives research support from the National Institute on Aging (P50 AG16574 [co-investigator], U01 AG06786 [co-investigator], and RO1 AG32306 [co-investigator]) and the Mangurian Foundation. Dr Goate has received honoraria from AstraZeneca for consultancy services; Howrey & Associates, Finnegan HC, and Dickstein Shapiro for expert testimony; and Pfizer, AstraZeneca, and Genentech for lectures; as well as royalties from Taconic.
NIA-LOAD/NCRAD Family Study Consortium Investigators: Robert Green, Neil Kowall, Lindsay Farrer, Boston University, Massachusetts; Jennifer Williamson, Vincent Santana, Columbia University, New York, New York; Donald Schmechel, Perry Gaskell, Kathleen Welsh-Bohmer, Margaret Pericak-Vance, Duke University, Durham, North Carolina; Bernardino Ghetti, Martin R. Farlow, Kelly Horner, Indiana University, Bloomington; John H. Growdon, Deborah Blacker, Rudolph E. Tanzi, Bradley T. Hyman, Massachusetts General Hospital, Boston; Bradley Boeve, Karen Kuntz, Lindsay Norgaard, Nathan Larson, Mayo Clinic, Rochester, Minnesota; Dana Kistler, Fracine Parfitt, Jenny Haddwow, Mayo Clinic, Jacksonville, Florida; Jeremy Silverman, Michal Schnaider Beeri, Mary Sano, Joy Wang, Rachel Lally, Mount Sinai School of Medicine, New York, New York; Nancy Johnson, Marcel Mesulum, Sandra Weintraub, Eileen Bigio, Northwestern University, Evanston, Illinois; Jeffery Kaye, Patricia Kramer, Jessica Payne-Murphy, Oregon Health and Science University, Portland; David Bennett, Holli Jacobs, Jeen-Soo Chang, Danielle Arends, Rush University, Chicago, Illinois; Lindy Harrell, University of Alabama at Birmingham; George Bartzokis, Jeffery Cummings, Po H. Lu, Usha Toland, University of California, Los Angeles; William Markesbery, Charles Smith, Alise Brickhouse, University of Kentucky, Lexington; John Trojanowski, Vivianna Van Deerlin, Elisabeth McCarty Wood, University of Pennsylvania, Philadelphia; Steven DeKosky, Robert Sweet, Elise Weamer, University of Pittsburgh, Pennsylvania; I. Helena Chui, Arousiak Varpetian, University of Southern California, Los Angeles; Ramon Diaz-Arrastia, Roger Rosenberg, Barbara Davis, University of Texas Southwestern, Dallas; Thomas Bird, Malia Rumbaugh, Gerard D. Schellenberg, Murray Raskind, University of Washington, Seattle; Alison Goate, John Morris, Joanne Norton, Denise Levitch, Betsy Grant, Mary Coats, Washington University at St Louis, Missouri.
Funding/Support: This study was supported by grants P30-NS069329-01, R01-AG035083, and K08-NS075094 from the National Institutes of Health. Samples from the National Cell Repository for Alzheimer's Disease, which receives government support under cooperative agreement grant U24 AG21886, were used in this study.
Additional Contributions: We thank contributors, including the Alzheimer's Disease Centers and the Washington University Neuromuscular Genetics Project, which collected samples used in this study, as well as patients and their families, whose help and participation made this work possible.