Accepted for Publication: October 11, 2012.
Published Online: March 25, 2013. doi:10.1001/jamaneurol.2013.1405
Author Contributions: Dr Evangelou had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Dixon, Tallantyre, Morgan, Morris, and Evangelou. Acquisition of data: Mistry, Dixon, Abdel-Fahim, Morgan, Morris, and Evangelou. Analysis and interpretation of data: Mistry, Tallantyre, Tench, Abdel-Fahim, Jaspan, Morgan, Morris, and Evangelou. Drafting of the manuscript: Mistry, Morris, and Evangelou. Critical revision of the manuscript for important intellectual content: Dixon, Tallantyre, Tench, Abdel-Fahim, Jaspan, Morgan, Morris, and Evangelou. Statistical analysis: Mistry, Tench, and Evangelou. Obtained funding: Morris and Evangelou. Administrative, technical, and material support: Dixon, Jaspan, Morgan, and Morris. Study supervision: Tallantyre, Jaspan, Morgan, Morris, and Evangelou.
Conflict of Interest Disclosures: Dr Mistry reports that he has been taken to scientific conferences at the expense of Bayer Schering Pharma, Merck Serono, and Novartis; these companies paid for the cost of his travels, accommodations, and registrations.
Funding/Support: This study was funded by the UK Multiple Sclerosis Society (grant 919) and the Medical Research Council (grant G0901321).
Role of the Sponsor: The sponsor of the study did not participate in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.