Accepted for Publication: December 21, 2012.
Published Online: March 11, 2013. doi:10.1001/jamaneurol.2013.2334
Author Contributions:Study concept and design: Ju, Duntley, and Holtzman. Acquisition of data: Ju, McLeland, Toedebusch, Duntley, and Morris. Analysis and interpretation of data: Ju, Xiong, Fagan, Morris, and Holtzman. Drafting of the manuscript: Ju and Holtzman. Critical revision of the manuscript for important intellectual content: Ju, McLeland, Toedebusch, Xiong, Fagan, Duntley, Morris, and Holtzman. Statistical analysis: Ju and Xiong. Obtained funding: Morris and Holtzman. Administrative, technical, and material support: Ju, McLeland, Toedebusch, Fagan, Morris, and Holtzman. Study supervision: Duntley and Holtzman.
Conflict of Interest Disclosures: Dr Duntley has consulted for UCB and Jazz Pharmaceuticals and received research support from UCB. Dr Morris has participated or is currently participating in clinical trials of antidementia drugs sponsored by Janssen Alzheimer Immunotherapy Program and Pfizer and has served as a consultant for or received speaking honoraria from Avid Radiopharmaceuticals, Eisai, Esteve, Janssen Alzheimer Immunotherapy Program, GlaxoSmithKline, Novartis, and Pfizer.
Funding/Support: This work was supported by National Institutes of Health (NIH) grants P01-NS074969 (Dr Holtzman), P01-AG026276 (Dr Morris), P50-AG05681 (Dr Morris), and P01-AG03991 (Dr Morris) and the Ellison Medical Foundation Senior Scholar Award (Dr Holtzman). We acknowledge the generous support of Fred Simmons and Olga Mohan. This publication was made possible by grant UL1 RR024992 from the National Center for Research Resources, a component of the NIH and NIH Roadmap for Medical Research.
Disclaimer: The contents of this article are solely the responsibility of the authors and do not necessarily represent the official view of the National Center for Research Resources or NIH.
Online-Only Material: Listen to an author interview about this article, and others, at http://bit.ly/MT7xg4.
Additional Contributions: Alison Goate, DPhil, director of the Charles F. and Joanne Knight Alzheimer's Disease Research Center Genetics Core, performed APOE genotyping.